| 张鹏,余得水.异丙酚联合羟考酮在子宫肌瘤腹腔镜术中的应用及对血清细胞因子水平的影响.[J].中南医学科学杂志.,2024,(6):1057-1060. |
| 异丙酚联合羟考酮在子宫肌瘤腹腔镜术中的应用及对血清细胞因子水平的影响 |
| Application of propofol combined with oxycodone in laparoscopy of uterine fibroids and its effect on serum cytokine levels |
| 投稿时间：2024-05-17 修订日期：2024-10-30 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.047 |
| 中文关键词: 子宫肌瘤 腹腔镜手术 异丙酚 羟考酮 麻醉效果 血清细胞因子 |
| 英文关键词:uterine fibroids laparoscopic surgery propofol oxycodone anesthetic effect serum cytokine |
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| 中文摘要: |
| 目的观察麻醉药物异丙酚联合羟考酮在子宫肌瘤腹腔镜术中的应用及对血清细胞因子水平的影响。 方法选择行子宫肌瘤腹腔镜术患者100例,分为对照组(48例,异丙酚+舒芬太尼)和观察组(52例,异丙酚+羟考酮)。比较两组麻醉指标、血流动力学、术后疼痛感、血清细胞因子水平及术后不良反应发生率。 结果观察组麻醉起效时间、术后苏醒时间及自主呼吸恢复时间均早于对照组,异丙酚、瑞芬太尼、肌松药的消耗量均低于对照组(P＜0.05)。插管时(T1)、气腹建立后5 min(T2)时,两组平均动脉压(MAP)均较麻醉前(T0)时上升,且T2时观察组低于对照组；与T0时比较,两组T1、T2、拔管后5 min(T3)时心率(HR)和T1、T2时脉搏血氧饱和度(SpO2)升高,T3时SpO2降低(P＜0.05)。T1、T2时观察组HR、SpO2高于对照组(P＜0.05)。观察组各时间点术后疼痛评分低于对照组(P＜0.05)。与麻醉前比较,两组苏醒后神经生长因子、白细胞介素-6及肿瘤坏死因子-α均上升,且观察组上升幅度小于对照组(P＜0.05)。两组术后总不良反应发生率差异无显著性(P＞0.05)。 结论在子宫肌瘤患者腹腔镜手术中,使用异丙酚联合羟考酮能取得更好应用效果,对改善麻醉效果、稳定血流动力学、缓解术后疼痛具有积极作用。 |
| 英文摘要: |
| AimTo observe the effects of propofol combined with oxycodone on serum cytokine levels in laparoscopy of uterine fibroids. MethodsA total of 100 patients who underwent hysteromyoma laparoscopy were selected and divided into control group (48 cases, propofol + sufentanil) and observation group (52 cases, propofol + oxycodone). Anesthesia indexes, hemodynamics, postoperative pain, serum cytokine levels and incidence of postoperative adverse reactions were compared between the two groups. ResultsThe onset time of anesthesia, postoperative recovery time, and spontaneous breathing recovery time in the observation group were all lower than those in the control group. The consumption of propofol, remifentanil, and muscle relaxants was also lower than that in the control group (P＜0.05). At the time of intubation (T1) and 5 minutes after the establishment of pneumoperitoneum (T2), the mean arterial pressure (MAP) of both groups increased compared with the level before anesthesia (T0), and the observation group was lower than the control group at T2; Compared with T0, both groups showed an increase in heart rate (HR) and pulse oxygen saturation (SpO2) at T1, T2, and 5 minutes after extubation (T3), while SpO2 decreased at T3 (P＜0.05). At T1 and T2, the HR and SpO2 of the observation group were higher than those of the control group (P＜0.05). The postoperative pain scores of the observation group were lower than those of the control group at each time point (P＜0.05). Compared with the levels before anesthesia, the levels of nerve growth factor, interleukin-6, and tumor necrosis factor-α increased in both groups after awakening, and the increase in the observation group was smaller than that in the control group (P＜0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups after surgery (P＞0.05). ConclusionDuring laparoscopic surgery for patients with uterine fibroids, propofol combined with oxycodone can achieve better application effects, which has positive effects on improving anesthesia effects, stabilizing hemodynamics and relieving postoperative pain. |
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