| 吴迪,赵运胜,张林光,李保林.老年COPD继发肺部真菌感染患者外周血(1-3)-β-D葡聚糖、淋巴细胞水平变化的临床意义.[J].中南医学科学杂志.,2024,(6):1043-1045, 1078. |
| 老年COPD继发肺部真菌感染患者外周血(1-3)-β-D葡聚糖、淋巴细胞水平变化的临床意义 |
| Clinical significance of changes in peripheral blood (1-3)-β-D-glucan and lymphocytes in elderly patients with pulmonary fungal infection secondary to COPD |
| 投稿时间：2023-08-23 修订日期：2024-10-08 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.043 |
| 中文关键词: 老年 COPD PFI (1-3)-β-D葡聚糖 淋巴细胞 |
| 英文关键词:elderly COPD PFI (1-3)-β-D glucan lymphocytes |
| 基金项目:秦皇岛市自然科学发展研究课题(2023ZR064) 作者简介:吴迪,主管检验师,研究方向为病原生物学检验,E-mail为yagg20221008@163.com。 |
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| 中文摘要: |
| 目的分析老年慢性阻塞性肺疾病(COPD)继发肺部真菌感染(PFI)患者外周血(1-3)-β-D葡聚糖、淋巴细胞水平变化的临床意义。 方法选取老年COPD继发PFI患者108例(PFI组)和老年COPD未继发PFI患者80例(非PFI组)。分析PFI组痰液病原菌分布情况；比较两组临床资料、外周血(1-3)-β-D葡聚糖、淋巴细胞亚群水平。分析COPD继发PFI的影响因素及(1-3)-β-D葡聚糖与淋巴细胞水平的相关性。 结果PFI组患者痰液病原菌主要为曲霉菌、假丝酵母菌和白念珠菌。PFI组(1-3)-β-D葡聚糖、CD3＋CD8＋高于非PFI组,CD3＋CD4＋、CD3＋CD4＋/CD3＋CD8＋低于非PFI组(P＜0.05)。外周血(1-3)-β-D葡聚糖与CD3＋CD4＋、CD3＋CD4＋/CD3＋CD8＋呈负相关,与CD3＋CD8＋呈正相关(P＜0.001)；(1-3)-β-D葡聚糖、CD3＋CD4＋、CD3＋CD4＋/CD3＋CD8＋均为老年COPD患者继发PFI的独立影响因素(P＜0.05)。 结论(1-3)-β-D葡聚糖、CD3＋CD4＋、CD3＋CD4＋/CD3＋CD8＋是老年COPD患者继发PFI的影响因素,可为其临床治疗提供参考。 |
| 英文摘要: |
| AimTo analyze the clinical significance of peripheral blood (1-3)-β-D glucan and lymphocytes in elderly patients with pulmonary fungal infection (PFI) secondary to chronic obstructive pulmonary disease (COPD). Methods108 elderly COPD patients with secondary PFI (PFI group) and 80 elderly COPD patients without secondary PFI (non-PFI group) were selected. The distribution of pathogenic bacteria in sputum of PFI group was analyzed. The clinical data, peripheral blood (1-3)-β-D glucan and lymphocyte subsets were compared between groups. The influencing factors of PFI secondary to COPD and the correlation between (1-3)-β-D glucan and lymphocytes were analyzed. ResultsThe main pathogens in the sputum of PFI group patients are Aspergillus, Candida, and Candida albicans. The levels of β-D-glucan and CD3＋CD8＋ in the PFI group (1-3) were higher than those in the non-PFI group, while the levels of CD3＋CD4＋ and CD3＋CD4＋/CD3＋CD8＋ were lower than those in the non-PFI group (P＜0.05). Peripheral blood (1-3)-β-D-glucan is negatively correlated with CD3＋CD4＋, CD3＋CD4＋/CD3＋CD8＋, and positively correlated with CD3＋CD8＋ (P＜0.001); (1-3)-β-D-glucan, CD3＋CD4＋, CD3＋CD4＋/CD3＋CD8＋ are independent influencing factors for secondary PFI in elderly COPD patients (P＜0.05). Conclusion(1-3)-β-D glucan, CD3＋CD4＋, and CD3＋CD4＋/CD3＋CD8＋ are the influencing factors of secondary PFI in elderly patients with COPD, which can provide reference for clinical treatment. |
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