| 刘芳芳,刘园园,李盼,张二娜,郭朝群,任倩影,高星.普罗布考联合丁苯酞治疗对ACI患者血清神经内分泌因子、炎症因子及神经功能的影响.[J].中南医学科学杂志.,2024,(6):1036-1038, 1068. |
| 普罗布考联合丁苯酞治疗对ACI患者血清神经内分泌因子、炎症因子及神经功能的影响 |
| The effects of probucol combined with butylphthalide treatment on serum neuroendocrine factors, inflammatory factors, and neurological function in ACI patients |
| 投稿时间：2024-03-15 修订日期：2024-10-25 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.041 |
| 中文关键词: 普罗布考 丁苯酞 ACI NSE hs-CRP 神经功能 |
| 英文关键词:probuco butylphthalide ACI NSE hs-CRP neurological function |
| 基金项目:保定市科技计划项目(2241ZF220) 作者简介:刘芳芳,硕士,主治医生,研究方向为神经内科疾病的诊治,E-mail为Liufangfangtao@163.com。 |
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| 中文摘要: |
| 目的探讨普罗布考联合丁苯酞治疗对急性脑梗死(ACI)患者血清神经内分泌因子、炎症因子水平及神经功能的影响。 方法选取ACI患者160例,随机均分为对照组(普罗布考)和观察组(普罗布考联合丁苯酞)。比较两组临床疗效、血清神经内分泌因子[神经元特异性烯醇化酶(NSE)、S100钙结合蛋白β(S100β)、脑源性神经营养因子(BDNF)]、炎症因子[超敏-C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]及神经功能。 结果观察组临床总有效率高于对照组(P＜0.05)；与治疗前比较,两组随治疗时间延长NIHSS评分、血清NSE、S100β、hs-CRP、IL-6、TNF-α水平均逐渐下降,BDNF逐渐上升,且治疗后观察组较同时间对照组变化更显著(P＜0.05)。 结论ACI患者应用普罗布考联合丁苯酞治疗疗效确切,可改善患者血清神经内分泌因子、炎症因子水平及神经功能,值得临床推广。 |
| 英文摘要: |
| AimTo investigate the effects of probucol combined with butylphthalide on serum levels of neuroendocrine factors and inflammatory factors, and neurological function in patients with acute cerebral infarction (ACI). Methods160 patients with ACI were selected and randomly divided into a control group (probucol) and an observation group (probucol combined with butylphthalide). The clinical efficacy, serum neuroendocrine factors (neuron specific enolase (NSE), S100 calcium binding protein β (S100β), brain derived neurotrophic factor (BDNF), inflammatory factors (high sensitivity C reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and neurological function, were compared between two groups. ResultsThe total clinical effective rate of the observation group was higher than that of the control group (P＜0.05). Compared with the parameters before treatment, the NIHSS scores, serum NSE, S100β, hs-CRP, IL-6, and TNF-α levels gradually decreased and BDNF gradually increased in both groups as the treatment time prolongs, and the changes in the observation group after treatment were more significant than those in the control group at the same time (P＜0.05). ConclusionThe use of probucol combined with butylphthalide for the treatment of ACI patients has a definite therapeutic effect and can improve the levels of serum neuroendocrine factors, inflammatory factors, and neurological function, which is worthy of clinical promotion. |
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