| 王涛,李元林,谢晓静,杨一帆,刘昊.阿立哌唑联合喹硫平治疗女性精神分裂症疗效及对生殖激素、糖脂代谢的影响.[J].中南医学科学杂志.,2024,(6):1032-1035. |
| 阿立哌唑联合喹硫平治疗女性精神分裂症疗效及对生殖激素、糖脂代谢的影响 |
| The efficacy of aripiprazole combined with quetiapine in the treatment of female schizophrenia and its effects on reproductive hormones and glucose and lipid metabolism |
| 投稿时间：2024-02-22 修订日期：2024-10-28 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.040 |
| 中文关键词: 阿立哌唑 喹硫平 女性精神分裂症 生殖激素 糖脂代谢 |
| 英文关键词:aripiprazole quetiapine female schizophrenia reproductive hormones glycolipid metabolism |
| 基金项目:阜阳市重点研究与开发计划项目(2023R074) 作者简介:王涛,副主任医师,研究方向为重性精神病的诊治,E-mail为gvtr1214@163.com。 |
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| 中文摘要: |
| 目的探讨阿立哌唑联合喹硫平治疗女性精神分裂症的疗效及对生殖激素、糖脂代谢的影响。 方法收集81例女性精神分裂症患者,按照治疗方案分为对照组(40例,喹硫平治疗)和联合组(41例,阿立哌唑联合喹硫平治疗)。评估两组临床疗效,比较两组治疗前后生殖激素、糖脂代谢及生活质量。 结果联合组治疗总有效率高于对照组(P＜0.05)；与治疗前比较,治疗后两组雌二醇(E2)降低,生活质量评分升高,对照组催乳素(PRL)升高,且治疗后联合组E2、生活质量评分高于对照组,PRL低于对照组；治疗后两组空腹血糖、糖化血红蛋白、胆固醇、甘油三酯、低密度脂蛋白胆固醇升高,高密度脂蛋白胆固醇降低,且对照组较联合组变化更为显著(P＜0.05)。 结论阿立哌唑联合喹硫平治疗女性精神分裂症疗效显著,对生殖激素、糖脂代谢影响小,此联合治疗方案值得推广。 |
| 英文摘要: |
| AimTo explore the efficacy of aripiprazole combined with quetiapine in the treatment of female schizophrenia and its effects on reproductive hormones and glucose and lipid metabolism. Methods81 female patients with schizophrenia were collected and divided into a control group (40 cases, treated with quetiapine) and a combination group (41 cases, treated with aripiprazole combined with quetiapine) according to the treatment plan. The clinical efficacy of two groups was evaluated, and the reproductive hormones, glucose and lipid metabolism, and quality of life before and after treatment, were compared. ResultsThe total effective rate of the combined treatment group was higher than that of the control group (P＜0.05); Compared with the levels before treatment, after treatment, both groups showed a decrease in estradiol (E2) and an increase in quality of life scores, while the control group showed an increase in prolactin (PRL), the E2 and quality of life scores in the combination group were higher than those in the control group, while PRL was lower than those in the control group; After treatment, fasting blood glucose, glycated hemoglobin, cholesterol, triglycerides, and low-density lipoprotein cholesterol increased in both groups, while high density lipoprotein cholesterol decreased,the changes in the control group were more significant than those in the combination group (P＜0.05). ConclusionThe combination therapy of aripiprazole and quetiapine has significant therapeutic effects on female schizophrenia, with little impact on reproductive hormones and glucose and lipid metabolism. This combination therapy is worth promoting. |
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