| 蒋洪宾,徐建来,季磊,陶传斌.伴T2DM的首发精神分裂症患者MAGE、HOMA-IR变化及其发生认知功能障碍的影响因素分析.[J].中南医学科学杂志.,2024,(6):1021-1024. |
| 伴T2DM的首发精神分裂症患者MAGE、HOMA-IR变化及其发生认知功能障碍的影响因素分析 |
| Analysis of MAGE, HOMA-IR changes and influencing factors of cognitive dysfunction in first-episode schizophrenia patients with T2DM |
| 投稿时间：2024-01-25 修订日期：2024-09-28 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.037 |
| 中文关键词: 2型糖尿病 首发精神分裂症 MAGE HOMA-IR 认知功能障碍 |
| 英文关键词:T2DM first-episode schizophrenia MAGE HOMA-IR cognitive impairment |
| 基金项目:南通市2023年药物政策与药学服务研究课题(2023NTPA20) 作者简介:蒋洪宾,主治医师,研究方向为精神疾病的诊治,E-mail为13584686968@163.com。 |
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| 中文摘要: |
| 目的分析伴2型糖尿病(T2DM)的首发精神分裂症患者平均血糖波动幅度(MAGE)、胰岛素抵抗指数(HOMA-IR)变化及其发生认知功能障碍的影响因素。 方法选取40例伴T2DM的首发精神分裂症且诊断为认知功能障碍的患者作为观察组,另外选取40例伴T2DM的首发精神分裂症但认知功能正常的患者作为对照组。比较两组血糖、血脂、血压指标水平及简易精神状态量表(MMSE)评分。采用Pearson法分析MMSE评分与HOMA-IR、糖化血红蛋白(HbA1c)、MAGE的相关性；采用Logistic多因素回归方法分析伴T2DM的首发精神分裂症患者发生认知功能障碍的影响因素。 结果观察组患者受教育年限、MMSE评分低于对照组,而胱抑素C(CysC)、HbA1c、MAGE、HOMA-IR水平高于对照组(P＜0.05)。伴T2DM的首发精神分裂症患者的MMSE评分与HOMA-IR、HbA1c、MAGE呈负相关(P＜0.05)。HOMA-IR、HbA1c、MAGE、CysC升高和受教育年限越少是伴T2DM的首发精神分裂症患者发生认知功能障碍的独立危险因素(P＜0.05)。 结论HOMA-IR、HbA1c、MAGE、CysC升高以及受教育年限越少是伴T2DM的首发精神分裂症患者发生认知功能障碍的影响因素。 |
| 英文摘要: |
| AimTo analyze the changes of mean amplitude of glycemic excursions (MAGE), homeostasis model assessment-insulin resistance (HOMA-IR) and their influencing factors of cognitive dysfunction in first-episode schizophrenia patients with type 2 diabetes mellitus (T2DM). MethodsForty first-episode schizophrenia patients with T2DM who were diagnosed with cognitive dysfunction were selected as the observation group. Additionally, another forty first-episode schizophrenia patients with T2DM but with normal cognitive function were selected as the control group. The levels of blood glucose, blood lipid, blood pressure indicators, and the scores of the mini-mental state examination (MMSE) were compared between the two groups. The correlation between the MMSE scores and the HOMA-IR, glycated hemoglobin (HbA1c), and MAGE was analyzed by using the Pearson method. The influencing factors for the occurrence of cognitive dysfunction in first-episode psychiatric patients with T2DM were analyzed by using the Logistic multivariate regression method. ResultsThe years of education and MMSE scores of the patients in the observation group were lower than those in the control group, while the levels of cystatin C (CysC), HbA1c, MAGE, and HOMA-IR were higher than those in the control group (P＜0.05). The MMSE scores of the first-episode psychiatric patients with T2DM were negatively correlated with HOMA-IR, HbA1c, and MAGE (P＜0.05). The increased HOMA-IR, HbA1c, MAGE, and CysC, as well as fewer years of education, were independent risk factors for the occurrence of cognitive dysfunction in first-episode schizophrenia patients with T2DM (P＜0.05). ConclusionThe incread HOMA-IR, HbA1c, MAGE, and CysC, as well as the fewer years of education are the influencing factors for the occurrence of cognitive dysfunction in first-episode schizophrenia patients with T2DM. |
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