| 刘常权,高凯,杜蓓,屈波.微创术后卡莫司汀联合替莫唑胺对GBM患者的疗效、STX8表达水平的影响及其预后的Logistics分析.[J].中南医学科学杂志.,2024,(6):984-987. |
| 微创术后卡莫司汀联合替莫唑胺对GBM患者的疗效、STX8表达水平的影响及其预后的Logistics分析 |
| The therapeutic efficacy, effect of STX8 expression level and prognostic Logistic analysis of camustine combined with temozolomide in patients with GBM after minimally invasive surgery |
| 投稿时间：2023-08-30 修订日期：2024-10-08 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.027 |
| 中文关键词: 胶质母细胞瘤 微创术 卡莫司汀 替莫唑胺 STX8 Logistics回归分析 |
| 英文关键词:GBM minimally invasive surgery carmustine temozolomide STX8 Logistic regression |
| 基金项目:河北省医学科学研究课题计划(20220646) 作者简介:刘常权,硕士,副主任医师,研究方向为胶质瘤的治疗,E-mail为lcq19931967376@163.com。 |
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| 中文摘要: |
| 目的观察微创术后卡莫司汀联合替莫唑胺对胶质母细胞瘤(GBM)患者的疗效、STX8表达水平的影响及其预后的Logistics分析。 方法回顾性分析本院收治的100例GBM患者的临床资料,将其均分为替莫唑胺组(术后单纯替莫唑胺治疗)和联合组(术后卡莫司汀联合替莫唑胺治疗)。比较两组患者疗效、STX8水平、不良反应及生存情况。采用单因素和多因素Logistics回归分析两组患者预后的影响因素。 结果联合组患者客观缓解率、总生存期、无进展生存期高于替莫唑胺组(P＜0.05),而STX8水平低于替莫唑胺组(P＜0.05)。两组不良反应发生率差异无统计学意义(P＞0.05)。单因素Logistics回归分析显示,年龄、性别、肿瘤部位、肿瘤大小、肿瘤分级、手术方式、化疗方案和STX8水平与GBM预后有关(P＜0.05)。多因素Logistics回归分析显示,化疗方案和STX8水平是影响GBM预后的独立危险因素(P＜0.05)。 结论微创术后卡莫司汀联合替莫唑胺治疗能够提高GBM患者的客观缓解率,降低STX8水平,延长生存期,且不增加不良反应。化疗方案和STX8水平是影响GBM预后的独立危险因素。 |
| 英文摘要: |
| AimTo investigate the efficacy, the impact of STX8 expression level, and prognostic Logistic analysis of carmustine combined with temozolomide in patients with glioblastoma multiformec (GBM) after minimally invasive surgery. MethodsA retrospective analysis was conducted on the clinical data of 100 patients with GBM admitted to our hospital, who were divided into the temozolomide group (treated with temozolomide alone after surgery) and the combination group (treated with camustine combined with temozolomide after surgery). The efficacy, STX8 expression levels, adverse reactions, and survival status of patients between two groups were compared. The influencing factors of prognosis were analyzed by univariate and multivariate Logistics regression analysis. ResultsThe objective remission rate, overall survival, and progression free survival of patients in the combination group were higher than those in the temozolomide group (P＜0.05), while the expression level of STX8 was lower than that in the temozolomide group (P＜0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Univariate Logistic regression analysis showed that age, gender, tumor location, tumor size, tumor grade, surgical approach, chemotherapy regimen, and STX8 expression level were associated with prognosis of GBM (P＜0.05). Multivariate Logistics regression analysis showed that chemotherapy regimen and STX8 expression level were independent risk factors affecting prognosis of GBM (P＜0.05). ConclusionThe combination of camustine and temozolomide treatment after minimally invasive surgery can improve the remission rate of GBM patients, reduce STX8 expression levels, prolong survival, without increasing adverse reactions. Chemotherapy regimen and STX8 expression level are independent risk factors affecting prognosis of GBM. |
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