| 朱燕阔,谢圆圆,李永豪,黄家旭,刘彦汝,何齐昌,郝恩刚,赵新涛.血清MCP-1、COR水平与急性冠脉综合征患者PCI术后发生谵妄的关系.[J].中南医学科学杂志.,2024,(6):980-983. |
| 血清MCP-1、COR水平与急性冠脉综合征患者PCI术后发生谵妄的关系 |
| Correlation between serum MCP-1, COR levels and delirium after PCI in patients with acute coronary syndrome |
| 投稿时间：2024-03-21 修订日期：2024-06-08 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.026 |
| 中文关键词: 急性冠脉综合征 经皮冠状动脉介入术 谵妄 单核细胞趋化蛋白-1 皮质醇 |
| 英文关键词:acute coronary syndrome PCI delirium MCP-1 COR |
| 基金项目:山东省医药卫生科技发展计划项目(202103010807) 作者简介:朱燕阔,副主任医师,研究方向为心血管疾病的诊治,E-mail为zh19z19@163.com。通信作者赵新涛,硕士,主治医师,研究方向为心血管疾病的诊治,E-mail为zhaoxintao2011@163.com。 |
| 作者 | 单位 | E-mail | | 朱燕阔 | 菏泽市牡丹人民医院心内科,山东菏泽 274000 | e-mail为zh19z19@163.com,e-mail为zhaoxintao2011@163.com | | 谢圆圆 | 菏泽市牡丹人民医院心内科,山东菏泽 274000 | | | 李永豪 | 菏泽市牡丹人民医院心内科,山东菏泽 274000 | | | 黄家旭 | 菏泽市牡丹人民医院心内科,山东菏泽 274000 | | | 刘彦汝 | 菏泽市牡丹人民医院心内科,山东菏泽 274000 | | | 何齐昌 | 菏泽市牡丹人民医院心内科,山东菏泽 274000 | | | 郝恩刚 | 聊城市第二人民医院心内科,山东聊城 252600 | | | 赵新涛 | 菏泽市牡丹人民医院心内科,山东菏泽 274000 | e-mail为zh19z19@163.com,e-mail为zhaoxintao2011@163.com |
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| 中文摘要: |
| 目的探讨血清单核细胞趋化蛋白-1(MCP-1)、皮质醇(COR)水平与急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)术后发生谵妄的关系。 方法选取行PCI介入术的298例ACS患者为研究对象,根据PCI术后7天内是否发生谵妄分为谵妄组、非谵妄组。比较两组临床资料及术前血清MCP-1、COR水平,分析ACS患者术后发生谵妄的影响因素,评估血清MCP-1、COR对术后谵妄的预测价值。 结果298例患者有31例在PCI术后7天内发生谵妄,发生率10.40%。谵妄组(31例)与非谵妄组(267例)年龄、睡眠障碍、视觉模拟评分(VAS)、血清MCP-1、COR水平比较差异有统计学意义(P＜0.05)。年龄≥65岁、MCP-1、COR、睡眠障碍、术后VAS疼痛评分≥4分是ACS患者PCI术后发生谵妄的危险因素(P＜0.05)。血清MCP-1、COR预测ACS患者术后发生谵妄的AUC分别为0.71、0.71,预测价值良好。 结论MCP-1、COR与年龄、睡眠障碍、术后疼痛共同影响ACS患者PCI术后谵妄的发生,且MCP-1、COR对术后发生谵妄具有一定预测价值。 |
| 英文摘要: |
| AimTo investigate the relationship between serum monocyte chemotactic protein-1 (MCP-1) , cortisol (COR) levels and delirium after percutaneous coronary intervention(PCI) in patients with acute coronary syndrome (ACS). Methods298 ACS patients who underwent PCI intervention were selected as the research subjects. They were divided into delirium group and non-delirium group based on whether delirium occurred within 7 days after PCI. The clinical data and preoperative serum MCP-1 and COR levels between two groups were compared, the influencing factors of postoperative delirium in ACS patients were analyzed, and the predictive value of serum MCP-1 and COR for postoperative delirium was analyzed. ResultsDelirium occurred in 31 of 298 patients within 7 days after PCI intervention, with an incidence of 10.40%. There were significant differences in age, sleep disorder, postoperative visual analogue scale (VAS), serum MCP-1 and COR levels between delirium group (31 cases) and non-delirium group (267 cases) (P＜0.05). Age ≥ 65 years, MCP-1, COR, sleep disorders, postoperative VAS ≥ 4 points were risk factors for delirium in ACS patients after PCI intervention (P＜0.05). The AUC of serum MCP-1 and COR in predicting postoperative delirium in ACS patients was 0.71 and 0.71, respectively, and the predictive value was good. ConclusionMCP-1, COR and age, sleep disorder, postoperative pain affect the occurrence of delirium after PCI in ACS patients, and MCP-1, COR have certain predictive value for postoperative delirium. |
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