| 陈俊,刘锋,刘俊英,刘娟.外周血PCT、hs-CRP、WBC、NEUT及N%对肺癌患者感染性发热的预测价值.[J].中南医学科学杂志.,2024,(6):958-960, 991. |
| 外周血PCT、hs-CRP、WBC、NEUT及N%对肺癌患者感染性发热的预测价值 |
| Predictive value of peripheral blood PCT, hs-CRP, WBC, NEUT and N% for infectious fever in patients with lung cancer |
| 投稿时间：2023-12-05 修订日期：2024-10-11 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.020 |
| 中文关键词: 肺癌 感染性发热 降钙素原 |
| 英文关键词:lung cancer infectious fever procalcitonin |
| 基金项目:陕西省中医药管理局科研项目(SZY-KJCYC-2023-053) 作者简介:陈俊,硕士,副主任医师,研究方向为乙肝抗病毒基础和临床,E-mail为vsaw1025@163.com。通信作者刘娟,主管检验师,研究方向为医学检验,E-mail为18409155959@163.com。 |
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| 中文摘要: |
| 目的研究外周血降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)、中性粒细胞计数(NEUT)及中性粒细胞指数(N%)对肺癌患者感染性发热的预测价值。 方法回顾性选择肺癌发热患者80例,根据发热原因分为感染热组(n＝49)和肿瘤热组(n＝31),根据抗感染治疗疗效分为有效组(n＝38)和无效组(n＝11)；纳入同期无发热的肺癌患者50例为对照组。比较各组PCT、hs-CRP、WBC、NEUT、N%水平。采用ROC曲线评估上述指标诊断肺癌感染性发热的效能。 结果感染热组和肿瘤热组PCT、hs-CRP、WBC、NEUT、N%水平高于对照组,且感染热组高于肿瘤热组；有效组PCT、WBC、NEUT、N%低于无效组(P＜0.05)。ROC曲线结果显示,PCT具有较高的诊断感染热价值(P＜0.05)。 结论hs-CRP、NEUT对肺癌感染性发热的诊断价值较小,PCT具有较高的鉴别感染热和肿瘤热的价值。 |
| 英文摘要: |
| AimTo study the predictive value of peripheral blood procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), white blood cell count (WBC), neutrophil count (NEUT) and neutrophil index (N%) for infectious fever in patients with lung cancer. MethodsA total of 80 patients with lung cancer and fever were retrospectively enrolled. According to fever causes, they were divided into infection fever group (n＝49) and tumor fever group (n＝31). According to curative effect of anti-infection therapy, they were divided into effective group (n＝38) and ineffective group (n＝11). A total of 50 lung cancer patients without fever during the same period were enrolled as control group. The levels of PCT, hs-CRP, WBC, NEUT and N% in different groups were compared. The diagnostic efficiency of the above indexes for infectious fever was evaluated by ROC curves. ResultsThe levels of PCT, hs CRP, WBC, NEUT, and N% in the infection heat group and tumor heat group were higher than those in the control group, and the infection heat group was higher than the tumor heat group; the PCT, WBC, NEUT, and N% in the effective group were lower than those in the ineffective group (P＜0.05). The ROC curves results showed that PCT has a high diagnostic value for infectious fever (P＜0.05). ConclusionThe accuracy rates of hs-CRP, NEUT are low in the diagnosis of infectious fever in patients with lung cancer, while PCT has high diagnosis value to differentiate infection fever and tumor fever. |
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