| 赵丹华,张利峰,徐海龙,窦海鹏.心宝丸联合西药治疗微血管心绞痛的效果观察及其作用机制探讨.[J].中南医学科学杂志.,2024,(6):946-949, 979. |
| 心宝丸联合西药治疗微血管心绞痛的效果观察及其作用机制探讨 |
| Observation of the effects of Xinbao pills combined with western drugs in the treatment of microvascular angina and exploration of its mechanism of action |
| 投稿时间：2023-12-17 修订日期：2024-10-07 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.017 |
| 中文关键词: 心宝丸 微血管心绞痛 西药 机制 疗效 |
| 英文关键词:Xinbao pills microvascular angina western medicine mechanism efficacy |
| 基金项目:河北省卫生健康委员会(20200588) 作者简介:赵丹华,硕士,主治医师,研究方向为心血管疾病的诊治,E-mail为zhaodh501@126.com。通信作者窦海鹏,硕士,副主任医师,研究方向为普腹外科疾病的诊治,E-mail为15903102299@163.com。 |
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| 中文摘要: |
| 目的观察心宝丸联合西药治疗微血管心绞痛的临床效果,并探讨其作用机制。 方法将本院微血管心绞痛患者200例随机均分为西药组及心宝丸组。西药组口服拜阿司匹林等西药治疗,心宝丸组在西药组基础上,加服心宝丸治疗。观察两组6个月后的临床效果。比较两组治疗前后内皮功能指标[血清内皮素-1(ET-1)、一氧化氮(NO)、ET-1/NO]、过氧化物酶体增殖物激活受体α(PPAR-α)、半乳糖凝集素-3(Gal-3)、血友病因子(vWF)、超敏C反应蛋白(hs-CRP)水平以及劳力型心绞痛发作频率、运动平板实验结果、冠状动脉血流储备(CFR)、不良反应发生情况。 结果心宝丸组总有效率高于西药组(P＜0.05)。与治疗前比较,治疗后两组Gal-3、PPAR-α、vWF、hs-CRP、ET-1、ET-1/NO比值、劳力型心绞痛发作频率、ST段最大压低幅度降低(P＜0.05),且心宝丸组低于西药组(P＜0.05)；NO、CFR升高,且心宝丸组高于西药组(P＜0.05)；总运动时间、ST段压低0.1 mV时间增长(P＜0.05),且心宝丸组长于西药组(P＜0.05)。 结论心宝丸联合西药治疗微血管心绞痛可降低心绞痛发作频率,改善运动平板实验结果,减轻症状,其机制可能与改善内皮功能和降低Gal-3、PPAR-α、vWF、hs-CRP水平有关。 |
| 英文摘要: |
| AimTo observe the clinical effects of Xinbao pills combined with western drugs in the treatment of microvascular angina, and to explore its mechanism of action. Methods200 patients with microvascular angina admitted to our hospital were randomly and equally divided into the western medicine group and the Xinbao pill group. The western medicine group was treated with aspirin and similar western medicine, the Xinbao pill group was treated with Xinbao pill on the basis of the western medicine group. The clinical effects of the two groups after 6 months were observed. The endothelial function indexes [endothelin-1 (ET-1), nitric oxide (NO), ET-1/NO], peroxisome proliferator activated receptor-α (PPAR-α), galectin-3 (Gal-3), von Willebrand factor (vWF), and hypersensitivity C-reactive protein (hs-CRP) levels, as well as frequency of exertional angina episodes, exercise tablet test results, coronary flow reserve (CFR), and the occurrence of adverse events of the two groups before and after the treatment were compared. ResultsThe total effective rate of Xinbao pill group was higher than that of the western medicine group (P＜0.05). Compared with the parameters before treatment, Gal-3, PPAR-α, vWF, hs-CRP, ET-1, ET-1/NO, frequency of exertional angina attacks, and ST-segment maximum depression were decreased in the two groups after treatment (P＜0.05), and the cardiobotanic pill group was lower than those of the western medicine group (P＜0.05). NO and CFR were increased, and the cardiobotanic pill group was higher than those of the western medicine group (P＜0.05). Total exercise time, ST-segment depression 0.1 mV time were increased (P＜0.05), and the Xinbaowan group was longer than those of the western medicine group (P＜0.05). ConclusionThe combination of Xinbao pills with western medicines in the treatment of microvascular angina reduces the frequency of angina attacks, improves the results of the exercise plate test, and reduces the symptoms, which may be related to the improvement of endothelial function and the reduction of Gal-3, PPAR-α, vWF, and hs-CRP levels. |
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