| 杜密稳,李翔华,贾亚静.终末期心力衰竭患者血NT-proBNP、CysC、Hcy变化及其与LVEF的关系.[J].中南医学科学杂志.,2024,(6):934-937. |
| 终末期心力衰竭患者血NT-proBNP、CysC、Hcy变化及其与LVEF的关系 |
| Changes in blood NT-proBNP, CysC, Hcy and their relationship with LVEF in patients with end-stage heart failure |
| 投稿时间：2024-05-21 修订日期：2024-10-29 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.014 |
| 中文关键词: 终末期心力衰竭 NT-proBNP CysC Hcy LVEF |
| 英文关键词:end-stage heart failure NT-proBNP CysC Hcy LVEF |
| 基金项目:山西省科技创新人才青年团队项目(202204051001028) 作者简介:杜密稳,硕士,副主任医师,研究方向为心脏重症与心肌病的诊治,E-mail为csau0102@163.com。 |
|
| 摘要点击次数: 52 |
| 全文下载次数: 20 |
| 中文摘要: |
| 目的分析终末期心力衰竭患者血N末端B型脑钠肽前体(NT-proBNP)、胱抑素(CysC)、同型半胱氨酸(Hcy)变化及其与左室射血分数(LVEF)的关系。 方法选取180例终末期心力衰竭患者为观察组,观察组按NYHA心功能分级分为Ⅲ级组81例、Ⅳ级组99例；并选取同期100例健康体检者为对照组。比较各组NT-proBNP、CysC、Hcy、LVEF水平,分析NT-proBNP、CysC、Hcy与LVEF的关系。 结果NT-proBNP、CysC、Hcy水平观察组高于对照组,Ⅳ级组高于Ⅲ级组；LVEF观察组低于对照组,Ⅳ级组低于Ⅲ级组(P＜0.05)。Pearson相关性分析显示,NT-proBNP、CysC、Hcy水平与LVEF呈负相关(P＜0.05)。多元线性回归分析显示,NT-proBNP、CysC、Hcy水平升高可能是LVEF的影响因素(P＜0.05)。 结论终末期心力衰竭患者血NT-proBNP、CysC、Hcy升高,且与LVEF呈负相关。 |
| 英文摘要: |
| AimTo analyze the changes of blood N-terminal B-type pro-brain natriuretic peptide (NT-proBNP), cystatin (CysC) and homocysteine (Hcy) in patients with end-stage heart failure, and their relationship with left ventricular ejection fraction (LVEF). MethodsA total of 180 patients with end-stage heart failure were selected as the observation group. They were divided into class Ⅲ group (81 cases) and class IV group (99 cases) according to NYHA class. Meanwhile, 100 healthy individuals were selected as the control group. The levels of NT-proBNP, CysC, Hcy, and LVEF were compared between the groups. The relationship between NT-proBNP, CysC, Hcy and LVEF was analyzed. ResultsThe levels of NT-proBNP, CysC and Hcy were higher in the observation group than in the control group, and higher in class IV group than in class Ⅲ group. LVEF was lower in the observation group than in the control group, and lower in class IV group than in class Ⅲ group (P＜0.05). Pearson correlation analysis found that the levels of NT-proBNP, CysC and Hcy were negatively correlated with LVEF (P＜0.05). Multiple linear regression analysis found that elevated levels of NT-proBNP, CysC and Hcy might be influencing factors of LVEF (P＜0.05). ConclusionThe levels of NT-proBNP, CysC and Hcy are elevated, and negatively correlated with LVEF in patients with end-stage heart failure. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|