| 胡海鹰,庾利,袁媛.T2DM患者SF、甲状腺功能指标与糖脂代谢水平、肥胖的关系.[J].中南医学科学杂志.,2024,(6):926-929. |
| T2DM患者SF、甲状腺功能指标与糖脂代谢水平、肥胖的关系 |
| Relationship of changes of serum SF and thyroid function index with levels of glucose and lipid metabolism and obesity in T2DM patients |
| 投稿时间：2024-01-11 修订日期：2024-04-27 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.012 |
| 中文关键词: 2型糖尿病 血清铁蛋白 甲状腺功能 糖脂代谢 肥胖 |
| 英文关键词:type 2 diabetes SF thyroid function glucose and lipid metabolism obesity |
| 基金项目:四川省干部保健科研课题(川干研2019-114) 作者简介:胡海鹰,技师,研究方向为内分泌和健康管理,E-mail为Gphhyxc@163.com。 |
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| 中文摘要: |
| 目的探讨2型糖尿病(T2DM)患者血清铁蛋白(SF)、甲状腺功能指标的变化及其与患者糖脂代谢水平、肥胖的关系。 方法选取184例T2DM患者,将甲状腺功能正常60例作为对照组、甲状腺功能减退92例作为甲减组、甲状腺功能亢进32例作为甲亢组。对比3组的血脂、血糖、腰围、体质指数(BMI)、SF、甲状腺功能指标；采用Pearson法分析SF、甲状腺功能指标与糖脂代谢指标、BMI、腰围的相关性。 结果3组患者空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)水平差异无显著性(P＞0.05)；甲减组甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、BMI、腰围测定值大于对照组和甲亢组(P＜0.05)。甲减组SF、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球体蛋白抗体(TGAb)水平高于对照组和甲亢组(P＜0.05);甲亢组游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲腺原氨酸(T3)高于对照组和甲减组(P＜0.05);甲亢组TSH水平低于对照组(P＜0.05)。SF与TG、LDLC呈正相关；FT3与FBG、HbA1c呈负相关；TSH与FBG、HbA1c呈负相关,与TG、LDLC、BMI、腰围呈正相关；TPOAb、TGAb与FBG、HbA1c呈负相关,TPOAb与TG、LDLC呈正相关,TGAb与TG、TC、LDLC呈正相关(P＜0.05)。 结论T2DM患者甲状腺功能紊乱(尤其是甲减患者)导致甲状腺激素水平异常、SF升高,与血脂代谢异常、BMI增加、腰围增大有一定的关系。 |
| 英文摘要: |
| AimTo explore the changes of serum ferritin (SF) and thyroid function indexes in patients with type 2 diabetes mellitus (T2DM), and their relationship with the levels of glucose and lipid metabolism and obesity in patients. MethodsA total of 184 patients with T2DM were selected. According to their thyroid function, 60 cases with normal thyroid function were taken as the control group, 92 cases with hypothyroidism were taken as the hypothyroidism group, and 32 cases with hyperthyroidism were taken as the hyperthyroidism group. The blood lipid, blood glucose, waist circumference, body mass index (BMI), serum SF and thyroid function indexes of the three groups were compared. The Pearson method was used to analyze the correlation between serum SF, thyroid function indexes and indexes of glucose and lipid metabolism. ResultsThere was no significant difference in fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), and high-density lipoprotein cholesterol (HDLC) levels among the three groups of patients (P＞0.05). The measured values of triglycerides (TG), low-density lipoprotein cholesterol (LDLC), BMI, and waist circumference in the hypothyroidism group were higher than those in the control group and hyperthyroidism group (P＜0.05). The levels of SF, thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), anti-thyroglobulin antibody (TGAb) in the hypothyroidism group were higher than those in the control group and hyperthyroidism group (P＜0.05). The levels of free triiodothyronine (FT3), free thyroxine (FT4), and triiodothyronine (T3) in the hyperthyroidism group were higher than those in the control group and hypothyroidism group (P＜0.05). The TSH level in the hyperthyroidism group was lower than that in the control group (P＜0.05). SF is positively correlated with TG and LDLC. FT3 is negatively correlated with FBG and HbA1c.TSH is negatively correlated with FBG and HbA1c, and positively correlated with TG, LDLC, BMI, and waist circumference. TPOAb and TGAb levels are negatively correlated with FBG and HbA1c, TPOAb is positively correlated with TG and LDLC, and TGAb is positively correlated with TG, TC, and LDLC (P＜0.05). ConclusionThyroid dysfunction (especially hypothyroidism patients) in T2DM leads to abnormal thyroid hormone levels and increased serum SF, which are related to abnormal lipid metabolism, increased BMI and increased waist circumference. |
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