| 黄薇媛,汤晨,马永驰,姬亚州.银杏叶提取物联合纤溶酶对SHL患者炎症因子及血管内皮功能的影响.[J].中南医学科学杂志.,2024,(6):922-925. |
| 银杏叶提取物联合纤溶酶对SHL患者炎症因子及血管内皮功能的影响 |
| Influence of the combination therapy of ginkgo biloba extract and plasmin on inflammatory factors, vascular endothelial function in SHL patients |
| 投稿时间：2023-11-27 修订日期：2024-04-19 |
| DOI：10.15972/j.cnki.43-1509/r.2024.06.011 |
| 中文关键词: 突发性耳聋 银杏叶提取物 纤溶酶 炎症因子 血管内皮功能 |
| 英文关键词:SHL ginkgo biloba extract plasmin inflammatory factors vascular endothelial function |
| 基金项目:安徽省教育厅项目(2021jyxm0386) 作者简介:黄薇媛,硕士,住院医师,研究方向为突发性耳聋的诊治,E-mail为Hwy353126143@163.com。通信作者姬亚州,硕士,主管技师,研究方向为血液病的诊断治疗,E-mail为15895906573@163.com。 |
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| 中文摘要: |
| 目的探讨银杏叶提取物联合纤溶酶对突发性耳聋(SHL)患者炎症因子及血管内皮功能的影响。 方法选取收治的350例SHL患者,随机均分为对照组和观察组。对照组给与纤溶酶治疗,观察组在对照组的基础上给与银杏叶提取物治疗。比较两组患者的临床疗效、临床症状改善情况、炎症因子、血管内皮功能以及不良反应发生情况。 结果观察组的临床总有效率高于对照组(P＜0.05),耳闷、眩晕、耳鸣消失时间以及听力恢复时间低于对照组(P＜0.05)。治疗后,两组患者的肿瘤坏死因子-α、白细胞介素-6、C反应蛋白及内皮素-1水平均降低(P＜0.05),且观察组低于对照组(P＜0.05)；两组患者的一氧化氮水平升高(P＜0.05),且观察组高于对照组(P＜0.05)。两组患者的不良反应总发生率比较差异无统计学意义(P＞0.05)。 结论银杏叶提取物与纤溶酶联合治疗SHL患者,在提高临床疗效、缓解临床症状、控制炎症反应及改善血管内皮功能方面具有明显效果,并具有一定治疗安全性。 |
| 英文摘要: |
| AimTo investigate the influence of the combination therapy of ginkgo biloba extract and plasmin on inflammatory factors, vascular endothelial function in patients with sudden hearing loss (SHL). Methods350 SHL patients were chosen, and depending on the random number table method, they were divided into control group (n＝175) and observation group(n＝175). The control group was treated with fibrinolytic enzyme, while the observation group was treated with ginkgo biloba extract in addition to the control group. The clinical curative effect, improvement of clinical symptoms, inflammatory factors, vascular endothelial function and occurrence of untoward effects were compared between the two groups. ResultsThe total clinical effective rate of observation group was apparently higher than that in the control group (P＜0.05), and the disappearance time of ear boredom, vertigo, tinnitus and hearing recovery time were apparently lower than those in the control group (P＜0.05). After treatment, the tumor necrosis factor-α, interleukin-6, C-reactive protein and endothelin-1 levels between the two groups were decreased (P＜0.05), and the observation group were lower compared with control group (P＜0.05). After treatment, the nitric oxide level between the two groups was increased (P＜0.05), and the observation group was apparently higher than that in control group (P＜0.05). The occurrence of untoward effects between the 2 groups were different (P＜0.05). ConclusionThe combination therapy of ginkgo biloba extract and plasmin in SHL patients had obvious effects in improving the clinical curative effect, relieving the clinical symptoms, controlling the inflammatory response and improving the vascular endothelial function, with certain therapeutic safety. |
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