| 陈文欣,郑康,周建斌.MMP-9在女性相关恶性肿瘤中作用的研究进展.[J].中南医学科学杂志.,2024,(5):873-876. |
| MMP-9在女性相关恶性肿瘤中作用的研究进展 |
| Research progress on the roles of MMP-9 in female-related malignancies |
| 投稿时间：2023-02-20 修订日期：2023-08-28 |
| DOI：10.15972/j.cnki.43-1509/r.2024.05.046 |
| 中文关键词: MMP-9 女性 恶性肿瘤 |
| 英文关键词:MMP-9 female malignancies |
| 基金项目:湖南省自然科学基金项目(2021JJ70112,2023JJ40101) |
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| 中文摘要: |
| 基质金属蛋白酶-9(MMP-9)是在多种生物过程中发挥重要作用的一种基质金属蛋白酶,可切割细胞外基质(ECM)蛋白,调控ECM重构,而ECM重塑是肿瘤细胞增殖、侵袭与转移等过程中的重要一环。同时MMP-9还能介导肿瘤微环境,因此,MMP-9对癌症的发生与发展起着一定的促进作用。本文对MMP-9在女性相关恶性肿瘤中的研究进展做一概述,为女性相关肿瘤的治疗、管理及预后等提供依据。 |
| 英文摘要: |
| Matrix metalloproteinase-9 (MMP-9) is a matrix metalloproteinase that plays an important role in a variety of biological processes, which can cleave extracellular matrix (ECM) proteins and regulate ECM remodeling, an important part of tumor proliferation, invasion and metastasis. Meanwhile, MMP-9 can also mediate the tumor microenvironment, therefore, MMP-9 plays a role in promoting the occurrence and development of cancer. This article provides an overview of the research progress of MMP-9 in female-related malignant tumors to provide a basis for treatment, management and prognosis in female-related tumors. |
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