| 石孙君,李爱华.血浆凝血功能指标与颅脑外伤继发迟发性脑出血的关系.[J].中南医学科学杂志.,2024,(5):864-867. |
| 血浆凝血功能指标与颅脑外伤继发迟发性脑出血的关系 |
| The relationship between plasma coagulation function indicators and delayed cerebral hemorrhage secondary to traumatic brain injury |
| 投稿时间：2023-12-15 修订日期：2024-03-28 |
| DOI：10.15972/j.cnki.43-1509/r.2024.05.044 |
| 中文关键词: D-二聚体 纤维蛋白原 活化凝血因子Ⅶ 颅脑外伤 迟发性脑出血 |
| 英文关键词:D-dimer fibrinogen activated coagulation factor Ⅶ craniocerebral injury delayed cerebral hemorrhage |
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| 中文摘要: |
| 目的探讨凝血功能指标血浆D-二聚体(D-D)、纤维蛋白原(Fg)、活化凝血因子Ⅶ(FⅦa)等与颅脑外伤继发迟发性脑出血的关系。 方法选取颅脑外伤继发迟发性脑出血患者88例为观察组,颅脑外伤无脑出血患者210例为对照组,比较两组临床资料,检测血浆D-D、Fg、FⅦa、凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)。分析凝血功能指标对迟发性脑出血的诊断效能以及迟发性脑出血的影响因素。 结果观察组患者年龄、GCS评分高于对照组(P＜0.05);观察组D-D、Fg、FⅦa、PT和APTT高于对照组(P＜0.05);观察组重度神经功能受损患者D-D、Fg、FⅦa、PT和APTT高于轻度受损和中度受损患者(P＜0.05);ROC分析发现,D-D、Fg、FⅦa、PT和APTT对迟发性脑出血的诊断具有良好的效能。Logistic回归分析结果显示:年龄、GCS评分、D-D、Fg及FⅦa是颅脑外伤继发迟发性脑出血的影响因素(P＜0.05)。 结论血浆D-D、Fg、FⅦa是颅脑外伤患者继发迟发性脑出血的影响因素,值得进一步研究。 |
| 英文摘要: |
| AimTo investigate the relationship between plasma D-dimer (D-D), fibrinogen (Fg), and activated coagulation factor Ⅶ (FⅦa), and delayed cerebral hemorrhage secondary to traumatic brain injury in terms of coagulation function. Methods88 patients with delayed cerebral hemorrhage secondary to traumatic brain injury were selected as the observation group, and 210 patients without cerebral hemorrhage due to traumatic brain injury were selected as the control group. The clinical data of the two groups were compared, and plasma D-D, Fg, FⅦa, prothrombin time (PT), as well as activated partial thromboplastin time (APTT), were detected. The diagnostic efficacy of coagulation function indicators for delayed cerebral hemorrhage and the influencing factors for delayed cerebral hemorrhage were analyzed. ResultsThe age and GCS score of patients in the observation group were higher than those in the control group (P＜0.05); The observation group had higher levels of D-D, Fg, FⅦa, PT, and APTT than the control group (P＜0.05); The D-D, Fg, FⅦa, PT, and APTT of patients with severe neurological impairment in the observation group were higher than those of patients with mild and moderate impairment (P＜0.05); ROC analysis found that D-D, Fg, FⅦa, PT, and APTT have good diagnostic efficacy for delayed cerebral hemorrhage. The results of logistic regression analysis showed that age, GCS score, D-D, Fg, and FⅦa were the influencing factors for delayed cerebral hemorrhage secondary to traumatic brain injury (P＜0.05). ConclusionPlasma D-D, Fg, and FⅦa are influencing factors for secondary delayed cerebral hemorrhage in patients with traumatic brain injury, and further research is warranted. |
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