| 张玉来,丁燕萍,吴舒梅.脑梗死患者血脂、凝血功能和炎症因子水平与早期神经功能恶化的关系.[J].中南医学科学杂志.,2024,(5):827-830. |
| 脑梗死患者血脂、凝血功能和炎症因子水平与早期神经功能恶化的关系 |
| Relationship between blood lipid, coagulation function, inflammatory factors and early neurological deterioration in patients with cerebral infarction |
| 投稿时间：2023-11-10 修订日期：2024-08-15 |
| DOI：10.15972/j.cnki.43-1509/r.2024.05.034 |
| 中文关键词: 脑梗死 早期神经功能恶化 血脂 凝血功能 炎症因子 |
| 英文关键词:cerebral infarction early neurological deterioration blood lipid coagulation function inflammatory factor |
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| 中文摘要: |
| 目的探讨脑梗死患者血脂、凝血功能和炎症因子水平与早期神经功能恶化(END)的关系。 方法选取行溶栓治疗的脑梗死患者97例,根据是否发生END分为END组(n＝21)和非END组(n＝76)。比较两组血脂[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)]、凝血功能[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(D-D)]和炎症因子[降钙素原(PCT)、C-反应蛋白(CRP)]水平,并分析各指标与END的关系。 结果END组合并糖尿病患者比例高于非END组,入院NIHSS评分及ΔNIHSS评分高于非END组(P＜0.05)。END组患者TC、TG、LDLC、FIB、D-D、PCT、CRP水平高于非END组,HDLC水平低于非END组(P＜0.05)。多因素Logistic回归分析显示,TC、TG、HDLC、LDLC、FIB、D-D、PCT、CRP是脑梗死患者发生END的影响因子(P＜0.05)。ROC分析显示,TC、TG、HDLC、LDLC、FIB、D-D、PCT、CRP预测脑梗死患者发生END均有一定的效能(P＜0.05),各指标联合检测预测脑梗死患者发生END的价值最高(P＜0.05)。 结论脑梗死患者血脂、凝血功能和炎症因子水平与END密切相关,其监测对预防END有重要临床意义。 |
| 英文摘要: |
| AimTo explore the relationship between blood lipid, coagulation function, inflammatory factors and early neurological deterioration (END) in patients with cerebral infarction. MethodsA total of 97 patients with cerebral infarction who underwent thrombolysis were enrolled. According to presence or absence of END, they were divided into END group (n＝21) and non-END group (n＝76). The blood lipid indexes [total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC)], coagulation function indexes [activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), D-dimer (D-D)] and inflammatory factors [procalcitonin (PCT), C-reactive protein (CRP)] were compared between the two groups, and the relationship between the above indexes and END was analyzed. ResultsThe proportion of patients with diabetes mellitus in END group was higher than that in non-END group, while scores of NIHSS and ΔNIHSS at admission were higher than those in non-END group (P＜0.05). The levels of TC, TG, LDLC, FIB, D-D, PCT and CRP in END group were higher than those in non-END group, while HDLC was lower than that in non-END group (P＜0.05). Multivariate Logistic regression analysis showed that TC, TG, HDLC, LDLC, FIB, D-D, PCT and CRP were influencing factors of END in patients with cerebral infarction (P＜0.05). ROC curves analysis showed that TC, TG, HDLC, LDLC, FIB, D-D, PCT and CRP all had certain predictive efficiency for END (P＜0.05), and predictive value of combined detection was the greatest (P＜0.05). ConclusionThe blood lipid, coagulation function and inflammatory factors are closely related with END in patients with cerebral infarction. Monitoring the above indexes is of important clinical significance for the prevention of END. |
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