| 田金媚,赵彩红.粪便移植对肠易激综合征患者肠道菌群及脑肠菌轴、IFN-γ、IL-4水平的调节作用.[J].中南医学科学杂志.,2024,(5):823-826. |
| 粪便移植对肠易激综合征患者肠道菌群及脑肠菌轴、IFN-γ、IL-4水平的调节作用 |
| Regulatory effects of fecal microbiota transplantation on gut microbiota, brain-enteric-bacteria axis, IFN-γ and IL-4 levels in patients with irritable bowel syndrome |
| 投稿时间：2023-10-19 修订日期：2024-08-10 |
| DOI：10.15972/j.cnki.43-1509/r.2024.05.033 |
| 中文关键词: 粪便移植 IBS IFN-γ IL-4 胃肠功能 脑肠菌轴 |
| 英文关键词:fecal microbiota transplantation IBS IFN-γ IL-4 gastrointestinal function brain-enteric-bacteria axis |
| 基金项目:衡水市科技计划项目(20210140827) |
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| 中文摘要: |
| 目的探究粪便移植对肠易激综合征(IBS)患者肠道菌群及脑肠菌轴、γ干扰素(IFN-γ)、白细胞介素(IL)-4水平的调节作用。 方法选取138例IBS患者,根据治疗方法分为粪便移植组(62例)和益生菌组(76例)。比较两组治疗前后肠道菌群、IFN-γ、IL-4、胃肠功能(血管活性肠肽、生长抑素、P物质、胃动素水平)、IBS生活质量量表(IBS-QOL)评分、IBS严重程度评分系统(IBS-SSS)、胃肠道症状评定量表(GSRS)评分及临床疗效。 结果治疗后,两组肠杆菌、肠球菌及酵母菌数量、IFN-γ、IL-4、IBS-QOL、IBS-SSS、GSRS评分、血管活性肠肽、生长抑素下降,乳酸杆菌、双歧杆菌数量、IL-4、P物质、胃动素升高；且粪便移植组改善较益生菌组更为显著(P＜0.05)。粪便移植组治疗总有效率高于益生菌组(P＜0.05)。 结论粪便移植可帮助IBS患者重建肠道微生态平衡,提高临床疗效及生活质量,促进胃肠功能恢复。 |
| 英文摘要: |
| AimTo explore the regulatory effect of fecal microbiota transplantation on gut microbiota, brain-enteric-bacteria axis, interferon-γ (IFN-γ) and interleukin-4 (IL-4) levels in patients suffered from irritable bowel syndrome. Methods138 patients with IBS were selected and divided into fecal transplantation group (62 cases) and probiotic group (76 cases), according to the treatment methods. Intestinal flora, IFN-γ, IL-4, gastrointestinal function (vasoactive intestinal peptide, somatostatin, substance P, motilin levels), as well as IBS quality of life scale (IBS-QOL), IBS severity system score (IBS-SSS), gastrointestinal symptom rating scale (GSRS) before and after treatment, and clinical efficacy of the two groups were compared. ResultsAfter treatment, the number of enterobacterium, enterococcus and yeast, IFN-γ, IL-4, IBS-QOL, IBS-SSS, GSRS scores, vasoactive intestinal peptides and somatostatin decreased in both groups, while the number of lactobacillus, bifidobacterium, IL-4, substance P and motilin increased. The improvement of fecal transplantation group was more significant than that of probiotic group (P＜0.05). The total effective rate of fecal transplantation group was higher than that of probiotic group (P＜0.05). ConclusionFecal transplantation can help IBS patients rebuild intestinal microecological balance, improve clinical efficacy and quality of life, and promote the recovery of gastrointestinal function. |
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