| 李书芹,杨志勇,吴忆帆,陆静忠.多发性骨髓瘤患者血清细胞因子和T细胞免疫功能水平与Mayo分层及预后的相关性.[J].中南医学科学杂志.,2024,(5):808-810, 842. |
| 多发性骨髓瘤患者血清细胞因子和T细胞免疫功能水平与Mayo分层及预后的相关性 |
| The correlation between serum cytokine and T cell immune function levels and Mayo stratification in patients with multiple myeloma |
| 投稿时间：2023-12-06 修订日期：2024-03-28 |
| DOI：10.15972/j.cnki.43-1509/r.2024.05.029 |
| 中文关键词: 多发性骨髓瘤 细胞因子 T细胞免疫功能 Mayo分层 预后 |
| 英文关键词:multiple myeloma cytokine T cell immune function Mayo stratification prognosis |
| 基金项目:上海市崇明区科学技术委员会可持续发展科技创新行动计划(CKY2020-37) |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的探讨多发性骨髓瘤患者血清细胞因子和T细胞免疫功能水平与Mayo分层及预后的相关性。 方法80例多发性骨髓瘤患者按Mayo分层分为高危组(18例)、中危组(38例)、标危组(24例)。比较各组患者血清细胞因子白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF),以及T细胞免疫功能指标CD3＋、CD4＋、CD8＋、NK细胞水平。采用Pearson相关性分析探讨各指标与Mayo分层及预后的相关性。 结果不同Mayo分层患者血清IL-6、IL-8、TNF-α、VEGF、CD3＋、CD4＋、CD8＋、CD4＋/CD8＋水平比较,差异均有显著性(P＜0.05);多发性骨髓瘤患者血清细胞因子IL-6、IL-8、TNF-α、VEGF与Mayo分层均呈正相关(P＜0.05);多发性骨髓瘤患者细胞免疫功能水平CD3＋、CD4＋、CD8＋、CD4＋/CD8＋与预后均呈负相关(P＜0.05)。 结论动态监测血清相关细胞因子及免疫功能有助于评价病情及预后。 |
| 英文摘要: |
| AimTo investigate the correlation between serum cytokine and T cell immune function levels and Mayo stratification and prognosis in patients with multiple myeloma. Methods80 patients with multiple myeloma were divided into high-risk group (18 cases), medium risk group (38 cases), and standard risk group (24 cases) according to Mayo stratification. The levels of serum interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), CD3＋, CD4＋, CD8＋, and NK cells in each group of patients were compared. Pearson correlation analysis was used to explore the correlation between IL-6, IL-8, TNF-α, VEGF, NLR, CD3＋, CD4＋, CD8＋, NK, CD4＋/CD8＋levels and Mayo stratification and prognosis. ResultsThe results showed that there were significant differences (P＜0.05) in the levels of serum IL-6, IL-8, TNF-α, VEGF, CD3＋, CD4＋, CD8＋, and CD4＋/CD8＋among patients with different Mayo stratification; IL-6, IL-8, TNF-α, and VEGF in patients with multiple myeloma were positively correlated with Mayo stratification (P＜0.05); The serum cytokines of CD3＋, CD4＋, CD8＋, CD4＋/CD8＋in patients with multiple myeloma were negatively correlated with prognosis (P＜0.05). ConclusionMayo stratification can predict prognosis, and dynamic monitoring of serum related cytokines and immune function can help evaluation of the condition and prognosis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|