| 向迪凯,敖伟,刘云.急性心肌梗死患者血清内脂素、Lp-a及CCL18水平与心功能和预后的关系.[J].中南医学科学杂志.,2024,(5):790-792. |
| 急性心肌梗死患者血清内脂素、Lp-a及CCL18水平与心功能和预后的关系 |
| The relationship between serum levels of visfatin, Lp-a, CCL18 and cardiac function, prognosis in patients with acute myocardial infarction |
| 投稿时间：2023-09-13 修订日期：2024-06-22 |
| DOI：10.15972/j.cnki.43-1509/r.2024.05.024 |
| 中文关键词: 急性心肌梗死 内脂素 Lp-a CCL18 心功能分级 |
| 英文关键词:acute myocardial infarction visfatin Lp-a CCL18 cardiac function grading |
| 基金项目:湖南创新型省份建设专项项目(2023JJ30819) |
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| 中文摘要: |
| 目的分析急性心肌梗死(AMI)患者血清内脂素、脂蛋白(Lp-a)及趋化因子配体18(CCL18)水平与心功能和预后的关系。 方法选择AMI患者100例(急性心梗组),按心功能分级或预后分亚组；另选健康体检者70例(对照组)。比较各组血清内脂素、Lp-a及CCL18水平。采用Spearman相关性分析各指标与心功能分级的相关性,采用ROC分析内脂素、Lp-a及CCL18预测患者预后的效能。 结果AMI组内脂素、Lp-a及CCL18高于对照组；随心功能分级增加,内脂素、Lp-a及CCL18水平逐渐升高；预后不良组内脂素、Lp-a及CCL18高于预后良好组(P＜0.05)。血清内脂素、Lp-a及CCL18与AMI患者心功能分级均呈正相关(P＜0.05)。血清内脂素、Lp-a、CCL18三者联合预测AMI患者预后的效能最高(P＜0.05)。 结论AMI患者血清内脂素、Lp-a、CCL18水平升高,与心功能密切相关,三者联合检测对预后有一定的预测价值。 |
| 英文摘要: |
| AimTo analyze the relationship between serum visfatin, lipoprotein a (Lp-a), chemokine ligand 18 (CCL18) and cardiac function, prognosis in patients with acute myocardial infarction (AMI). MethodsA total of 100 patients with AMI were enrolled as AMI group, and they were divided into subgroups according to cardiac function grading and prognosis. A total of 70 healthy controls were enrolled as control group. The levels of serum visfatin, Lp-a and CCL18 in different groups were compared. The correlation between serum indexes and cardiac function grading was analyzed by Spearman correlation analysis. The predictive efficiency of serum visfatin, Lp-a and CCL18 for prognosis was analyzed by ROC curves. ResultsThe visfatin, Lp-a and CCL18 in AMI group were higher than those in control group. With the increase of cardiac function grading, visfatin, Lp-a and CCL18 were gradually increased. The visfatin, Lp-a and CCL18 in poor prognosis group were higher than those in good prognosis group (P＜0.05). Visfatin, Lp-a and CCL18 were positively correlated with cardiac function grading (P＜0.05). The predictive efficiency of visfatin combined with Lp-a and CCL18 for prognosis of AMI patients was the highest (P＜0.05). ConclusionThe levels of serum visfatin, Lp-a and CCL18 are increased in AMI patients, which are closely related with cardiac function. The combined detection of the three indexes has certain prognostic value. |
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