| 常雪岩,周凌.益气通窍饮联合糖皮质激素治疗慢性鼻-鼻窦炎的疗效及对黏膜组织重塑的影响.[J].中南医学科学杂志.,2024,(5):739-742, 789. |
| 益气通窍饮联合糖皮质激素治疗慢性鼻-鼻窦炎的疗效及对黏膜组织重塑的影响 |
| Effects of Yiqitongqiaoyin combined with glucocorticoid on chronic rhinosinusitis and its impact on mucosal tissue remodeling |
| 投稿时间：2024-06-12 修订日期：2024-08-28 |
| DOI：10.15972/j.cnki.43-1509/r.2024.05.011 |
| 中文关键词: 益气通窍饮 糖皮质激素 慢性鼻-鼻窦炎 疗效 黏膜组织重塑 |
| 英文关键词:Yiqitongqiaoyin glucocorticoid CRS curative effect mucosal tissue remodeling |
| 基金项目:国家自然科学基金(81874495) |
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| 中文摘要: |
| 目的观察益气通窍饮联合糖皮质激素治疗慢性鼻-鼻窦炎(CRS)的疗效及对黏膜组织重塑的影响。 方法选取70例本院收治的CRS患者为研究对象,根据治疗方法不同均分为对照组(糖皮质激素治疗)和观察组(在对照组基础上予以益气通窍饮治疗)。比较两组患者治疗疗效以及两组患者治疗前后的中医证候积分、生活质量[鼻腔鼻窦结局测量-20(SNOT-20)评分]、客观症状(Lund-Kennedy、Lund-Mackay评分)、黏膜组织重塑情况[鼻黏膜损伤、基底膜厚度、转化生长因子-β1(TGF-β1)阳性细胞数]、鼻黏膜纤毛清除功能、嗜酸性粒细胞阳离子蛋白(ECP)、γ干扰素(IFN-γ)、免疫球蛋白E(IgE)、白细胞介素-6(IL-6)水平。 结果观察组总有效率高于对照组(P＜0.05)。与治疗前比较,治疗后两组患者的中医证候积分、SNOT-20评分、Lund-Kennedy评分、Lund-Mackay评分、基底膜厚度、TGF-β1阳性细胞数以及ECP、IFN-γ、IgE、IL-6水平均降低,且观察组低于对照组(P＜0.05)；而鼻黏膜损伤(0~1级)占比、鼻黏膜清除率、清除速度升高,且观察组高于对照组(P＜0.05)。 结论益气通窍饮联合糖皮质激素治疗CRS具有良好的疗效,有助于抑制鼻黏膜组织重塑,改善患者的证候、生活质量和临床症状,有助于患者鼻黏膜纤毛清除功能的恢复,降低患者的炎症反应和ECP水平。 |
| 英文摘要: |
| AimTo observe the effects of Yiqitongqiaoyin combined with glucocorticoid on chronic rhinosinusitis (CRS) and its impact on mucosal tissue remodeling. MethodsSeventy patients with CRS admitted to our hospital were selected as the research subjects and divided into a control group (treated with glucocorticoids) and an observation group (treated with Yiqitongqiaoyin on the basis of the control group) according to different treatment methods, with 35 cases in each group. The therapeutic effects of the two groups, as well as their traditional Chinese medicine syndrome scores, quality of life (SNOT-20 scale), objective symptoms (Lund-Kennedy and Lund-Mackay score), mucosal tissue remodeling indicators (nasal mucosal injury, basement membrane thickness, positive for transforming growth factor β1 (TGF-β1), nasal mucosal ciliary clearance function, eosinophil cationic protein (ECP), interferon gamma (IFN-γ), immunoglobulin E (IgE), and interleukin-6 (IL-6) levels before and after treatment of the two groups were compared. ResultsThe total effective rate of the observation group was higher than that of the control group (P＜0.05). Compared with the parameters before treatment, the traditional Chinese medicine syndrome score, SNOT-20 score, Lund-Kennedy score, Lund-Mackay score, basement membrane thickness, number of TGF-β 1 positive cells, and levels of ECP, IFN-γ, IgE, and IL-6 in both groups were decreased after treatment, and the observation group was lower than the control group (P＜0.05). The proportion of nasal mucosal injury (grade 0-1), nasal mucosal clearance rate, and clearance speed were increased, and the observation group was higher than the control group (P＜0.05). ConclusionThe combination of Yiqitongqiaoyin combined with glucocorticoid has a good therapeutic effect on CRS, which helps to inhibit mucosal tissue remodeling, improve patients' syndrome, quality of life, and clinical symptoms, restore nasal mucosal ciliary clearance function, and reduce inflammation and ECP levels in patients. |
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