| 徐月亮,康树宏,鲍培龙.老年肺癌患者肺部侵袭性真菌感染影像学CT特征与PBMCs中CLRs表达的关系.[J].中南医学科学杂志.,2024,(4):657-660. |
| 老年肺癌患者肺部侵袭性真菌感染影像学CT特征与PBMCs中CLRs表达的关系 |
| Relationship between CT features of elderly lung cancer patients with pulmonary invasive fungal infection and the expression of CLRs in PBMCs |
| 投稿时间：2023-04-23 修订日期：2024-05-15 |
| DOI：10.15972/j.cnki.43-1509/r.2024.04.039 |
| 中文关键词: 肺癌 老年 肺部侵袭性真菌感染 外周血单个核细胞 C型凝集素受体 |
| 英文关键词:lung cancer elderly pulmonary invasive fungal infection peripheral blood mononuclear cells C-type lectin receptor |
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| 中文摘要: |
| 目的探究肺部侵袭性真菌感染老年肺癌患者影像学CT特征与外周血单个核细胞(PBMCs)中C型凝集素受体(CLRs)表达的关系。 方法选取100例老年肺癌患者,按有无肺部侵袭性真菌感染分为感染组和无感染组。比较两组影像学CT特征和PBMCs中CLRs的表达。COX回归分析患者感染的影响因素,明确影像学CT特征与PBMCs中CLRs表达的关系。 结果与无感染组比较,感染组年龄≥80岁、应用糖皮质激素、应用抗生素时间＞14天、侵入性操作、影像学CT分型弥散型占比明显升高,而影像学CT分型结节型占比、CLRs表达明显降低(P＜0.05)。COX回归分析提示,年龄、应用糖皮质激素、应用抗生素时间、侵入性操作、CLRs表达是患者感染的影响因素(P＜0.05)。感染组影像学CT特征为弥散型的患者CLRs表达明显低于其他型患者(P＜0.05)。 结论老年肺癌合并肺部侵袭性真菌感染患者影像学CT特征与PBMCs中CLRs表达有关,严格控制抗菌药物和激素的使用、减少侵入性操作,对降低患者肺部侵袭性真菌感染的发生风险有积极作用。 |
| 英文摘要: |
| AimTo investigate the relationship between CT features of elderly lung cancer patients with pulmonary invasive fungal infection and the expression of C-type lectin receptors (CLRs) in peripheral blood mononuclear cells (PBMCs). MethodsOne hundred elderly lung cancer patients were divided into infection group and non-infection group based on the presence or absence of invasive fungal infection in the lungs. CT features and expression of CLRs in PBMCs of the two groups were compared. COX regression analysis was performed to screen the influencing factors of infection. The relationship between CT features and the expression of CLRs in PBMCs was clarified. ResultsCompared with the non-infection group, the proportions of patients ≥80 years old, using glucocorticoids, time of using antibiotics ＞14 days, invasive procedures and CT imaging classification as diffuse type were increased in the infection group, while the proportion of CT classification as nodular type and the expression level of CLRs were decreased significantly (P＜0.05). COX regression analysis indicated that age, use of glucocorticoids, time of using antibiotics, invasive procedures, and expression of CLRs were influencing factors of infection (P＜0.05). The expression levels of CLRs in patients with diffuse type were significantly lower than those in patients with other types in the infection group (P＜0.05). ConclusionCT features of elderly lung cancer patients with pulmonary invasive fungal infection are related to the expression of CLRs in PBMCs. Strictly controlling the use of antibiotics and hormones and reducing invasive procedures plays a positive role in reducing the risk of pulmonary invasive fungal infection. |
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