| 李天保,胡幼霞,麦维铸,邹旭梅,陈丽兰.血栓弹力图联合hs-CRP、HbA1c水平预测进展性缺血性脑卒中的临床价值.[J].中南医学科学杂志.,2024,(4):638-641. |
| 血栓弹力图联合hs-CRP、HbA1c水平预测进展性缺血性脑卒中的临床价值 |
| The clinical value of thromboelastography combined with hs-CRP and HbA1c levels in predicting progressive ischemic stroke |
| 投稿时间：2023-04-07 修订日期：2023-11-27 |
| DOI：10.15972/j.cnki.43-1509/r.2024.04.034 |
| 中文关键词: 超敏C反应蛋白 糖化血红蛋白 血栓弹力图 进展性缺血性脑卒中 预测价值 |
| 英文关键词:hypersensitive C-reactive glycosylated hemoglobin thromboelastogram progressive ischemic stroke predictive value |
| 基金项目:佛山市自筹经费类科技创新项目(2220001004029) |
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| 中文摘要: |
| 目的探究血栓弹力图联合超敏C反应蛋白(hs-CRP)、糖化血红蛋白(HbA1c)水平对进展性缺血性脑卒中的预测价值。 方法回顾性分析收治的120例急性缺血性脑卒中患者,分为进展组37例和非进展组83例,同期120例健康体检者作为对照组。收集所有研究对象的一般资料、hs-CRP、HbA1c水平和血栓弹力图参数,对其发生进展性缺血性脑卒中进行Logistic多因素分析,采用ROC对其hs-CRP、HbA1c和血栓弹力图参数预测价值进行分析。 结果进展组美国国立卫生研究院卒中量表评分高于非进展组(P＜0.05)。与对照组比较,进展组和非进展组hs-CRP、HbA1c水平更高,且进展组高于非进展组,反应时间和凝固时间更短,且进展组短于非进展组,凝固角和最大振幅更大,且进展组大于非进展组(P＜0.05)；多因素Logistic回归性分析发现,hs-CRP、HbA1c、凝固时间、凝固角和最大振幅是急性缺血性脑卒中患者出现进展的影响因素(P＜0.05)。ROC分析可得,hs-CRP、HbA1c和血栓弹力图3项指标预测急性缺血性脑卒中患者发生进展的AUC分别为0.751、0.732、0.737,其联合预测效能最高,灵敏度和特异度分别为0.703和0.916。 结论hs-CRP、HbA1c和血栓弹力图对于进展性缺血性脑卒中的发生均有较高的预测价值,三者联合预测的整体效能最佳。 |
| 英文摘要: |
| AimTo explore the predictive value of thromboelastogram combined with hypersensitive C-reactive protein (hs-CRP) and glycosylated hemoglobin (HbA1c) levels for progressive ischemic stroke. MethodsRetrospective analysis was conducted on 120 patients with acute ischemic stroke admitted, with a progressive group of 37 cases and a non-progressive group of 83 cases, and during the same period, 120 healthy individuals underwent physical examinations were used as the control group. General information, hs-CRP, HbA1c levels, and thromboelastography parameters of all study subjects were collected. Logistic multivariate analysis was performed on the occurrence of progressive ischemic stroke, and the predictive value of hs-CRP, HbA1c, and thromboelastography parameters were analyzed by using ROC. ResultsThe national institute of health stroke scale of the progressive group was higher than that of the non-progressive group (P＜0.05). Compared with the control group, the hs-CRP and HbA1c levels were higher in the progressive group and non-progressive group, and the progressive group was higher than those in the non-progressive group. The reaction time and coagulation time were shorter, and the progressive group was shorter than those in the non-progressive group. The coagulation angle and maximum amplitude were larger, and the progressive group was greater than those in the non-progressive group (P＜0.05). Multivariate Logistic regression analysis found that hs-CRP, HbA1c, coagulation time, coagulation angle, and maximum amplitude were the influencing factors for the progression of acute ischemic stroke patients (P＜0.05). Through ROC curve analysis, it can be concluded that the AUC of hs-CRP, HbA1c, and thromboelastography in predicting the progression of acute ischemic stroke patients is 0.751,0.732, and 0.737, respectively. The combination had the highest predictive efficacy, with sensitivity and specificity of 0.703 and 0.916, respectively. ConclusionHs-CRP, HbA1c and thromboelastogram have high predictive value for the occurrence of progressive ischemic stroke, and the combination of the three has the best overall effect for prediction. |
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