| 江婷婷,刘伟,刘会前.帕罗西汀联合喹硫平治疗双相情感障碍抑郁发作的临床疗效.[J].中南医学科学杂志.,2024,(4):632-634. |
| 帕罗西汀联合喹硫平治疗双相情感障碍抑郁发作的临床疗效 |
| Clinical efficacy of Paroxetine combined with Quetiapine in the treatment of depressive episode of bipolar disorder |
| 投稿时间：2023-12-06 修订日期：2024-03-25 |
| DOI：10.15972/j.cnki.43-1509/r.2024.04.032 |
| 中文关键词: 帕罗西汀 喹硫平 双相情感障碍 抑郁发作 |
| 英文关键词:paroxetine quetiapine bipolar disorder depressive episode |
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| 中文摘要: |
| 目的评估帕罗西汀联合喹硫平治疗双相情感障碍(BPD)抑郁发作的临床疗效。 方法选取100例BPD抑郁发作患者,随机均分为对照组(帕罗西汀)、观察组(帕罗西汀+喹硫平)。比较两组治疗有效率、汉密尔顿抑郁量表-17(HAMD-17)评分、抑郁水平评定量表(CES-D)评分、炎症因子、生活质量综合评定问卷(GQOLI-74)评分、药物不良反应率。 结果观察组治疗有效率高于对照组(P＜0.05)。治疗6周后,观察组HAMD-17评分、CES-D评分、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1降低,IL-10、GQOLI-74评分升高(P＜0.05),且观察组改善优于对照组(P＜0.05)。两组药物不良反应无差异。 结论BPD抑郁发作患者采用帕罗西汀联合喹硫平治疗,可以改善TNF-α、IL-1、IL-10水平,增强疗效,缓解抑郁情绪。 |
| 英文摘要: |
| AimTo evaluate the clinical efficacy of paroxetine plus quetiapine in patients with bipolar disorder (BPD) depressive episodes. Methods100 patients with BPD depressive episode were randomly and equally divided into control group (Paroxetine) and observation group (Paroxetine+Quetiapine). The effective rates of treatment, Hamilton depression scale 17 (HAMD-17) scores, depression rating scale (CES-D) scores, inflammatory factors, GQOLI-74 scores, and drug adverse reaction rates between two groups were compared. ResultsThe effective rate of observation group was higher than that of control group (P＜0.05). The HAMD-17 score, CES-D score, tumor necrosis factor alpha (TNF-α), and interleukin-1 (IL-1) were lower in the observation group than those in the control group, while IL-10 and GQOLI-74 score were higher in the observation group than those of the control group after 6 weeks of treatment (P＜0.05), and the observation group showed better improvement than the control group (P＜0.05). There was no difference in adverse reactions between the two groups. ConclusionParoxetine combining Quetiapine can change the levels of TNF-α, IL-1, IL-10 in patients with BPD depression, alleviate depression, and improve quality of life, making it worth promoting. |
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