| 刘国霖,李姣姣,金瑞,祁文元,宛杨,梅莉.同型半胱氨酸-叶酸代谢对妊娠期高血压疾病的诊断价值.[J].中南医学科学杂志.,2024,(4):617-619. |
| 同型半胱氨酸-叶酸代谢对妊娠期高血压疾病的诊断价值 |
| Diagnostic value of homocysteine-folate metabolism to hypertensive disorders of pregnancy |
| 投稿时间：2024-01-16 修订日期：2024-05-18 |
| DOI：10.15972/j.cnki.43-1509/r.2024.04.028 |
| 中文关键词: 同型半胱氨酸 叶酸代谢 妊娠期高血压疾病 |
| 英文关键词:homocysteine folate metabolism hypertensive disorders of pregnancy |
| 基金项目:阜阳市科技局课题(Fk202081036) |
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| 中文摘要: |
| 目的评估同型半胱氨酸(Hcy)-叶酸代谢对妊娠期高血压疾病(HDP)的诊断价值。 方法选取本院孕24～28周孕妇411例,采用液相质谱联用技术测定其外周血叶酸、甲酰四氢叶酸、甲基四氢叶酸、Hcy水平。根据Hcy水平分为Hcy阳性组与阴性组,根据血压相关情况分为HDP组与非HDP组(NHDP组)。比较Hcy阳性组与阴性组HDP、叶酸、甲酰四氢叶酸、甲基四氢叶酸异常发生率；比较HDP组和NHDP组Hcy、叶酸、甲酰四氢叶酸、甲基四氢叶酸水平。采用Pearson相关性分析Hcy与HDP的相关性,ROC分析Hcy对HDP发生的诊断价值。 结果411例孕妇发生高Hcy 86例(20.92%),叶酸异常2例(0.49%),甲酰四氢叶酸异常79例(19.22%),甲基四氢叶酸异常35例(8.52%),发生HDP 58例(14.11%)。Hcy阳性组HDP发生率、甲酰四氢叶酸异常发生率高于Hcy阴性组(P＜0.05)；Hcy阳性组中HDP发生的孕周大于Hcy阴性组(P＜0.05)。HDP组Hcy、孕前体质量、孕前体质指数(BMI)、分娩体质量均高于NHDP组(P＜0.05)。HDP的发生与Hcy、孕前体质量、孕前BMI、分娩体质量呈显著相关性(P＜0.05)。Hcy对HDP具有一定的诊断价值。 结论孕妇甲酰四氢叶酸异常、高Hcy发生率高,高Hcy血症与妊娠期高血压疾病发生率密切相关；Hcy可能成为预测HDP发生的血清学标志物。 |
| 英文摘要: |
| AimTo evaluate the diagnostic value of homocysteine (Hcy)-folate metabolism to hypertensive disorders of pregnancy (HDP). Methods411 pregnant women aged 24－28 weeks in our hospital were selected and their peripheral blood folate, formyltetrahydrofolate, methyltetrahydrofolate, and Hcy levels were measured by using liquid chromatography-mass spectrometry technology. They were divide into Hcy positive group and negative group based on Hcy levels, or HDP group and non HDP group (NHDP group) based on blood pressure related conditions. The incidence of HDP, folate, formyltetrahydrofolate, and methyltetrahydrofolate abnormalities between the Hcy positive group and the negative group were compared. The levels of Hcy, folate, formyltetrahydrofolate, and methyltetrahydrofolate in patients between the HDP group and NHDP group were compared. Pearson correlation analysis was used to examine the correlation between Hcy and HDP, and ROC analysis to assess the diagnostic value of Hcy in the occurrence of HDP. ResultsOf 411 pregnant women,there were 86 cases of high Hcy (20.92%), 2 cases of folate abnormalities (0.49%), 79 cases of formyltetrahydrofolate abnormalities (19.22%), 35 cases of methyltetrahydrofolate abnormalities (8.52%), and 58 cases of HDP (14.11%). The incidence of HDP and abnormal formyltetrahydrofolate in the Hcy positive group were higher than that in the Hcy negative group (P＜0.05). The gestational age at which HDP occurred in the Hcy positive group was greater than that in the Hcy negative group (P＜0.05). The Hcy, prepregnancy body mass, prepregnancy body mass index (BMI), and delivery body mass of the HDP group were all higher than those of the NHDP group (P＜0.05). The occurrence of HDP is significantly correlated with high Hcy, prepregnancy body mass, prepregnancy BMI, and delivery body mass (P＜0.05). Hcy has certain diagnostic value for HDP. ConclusionPregnant women with a high incidence of abnormal levels of formyltetrahydrofolate and high Hcy, and high Hcy is closely related to the incidence of gestational hypertension. Hcy may be a serological marker for predicting the occurrence of HDP. |
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