| 林学贤,张亚和,崔光锐.血清8-OHdG、T-cad与急性胰腺炎患者病情严重程度、疾病转归的关系.[J].中南医学科学杂志.,2024,(4):592-595. |
| 血清8-OHdG、T-cad与急性胰腺炎患者病情严重程度、疾病转归的关系 |
| The relationship between serum 8-OHdG, T-cad and the severity of illness and outcome of patients with acute pancreatitis |
| 投稿时间：2023-07-11 修订日期：2024-05-15 |
| DOI：10.15972/j.cnki.43-1509/r.2024.04.021 |
| 中文关键词: 8-OHdG T-cad 急性胰腺炎 病情 预后 |
| 英文关键词:8-hydroxy-deoxyguanosine T-cadherin acute pancreatitis disease condition prognosis |
| 基金项目:海南省卫生健康行业科研项目(20A200330) |
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| 中文摘要: |
| 目的探讨血清8-羟基脱氧鸟苷(8-OHdG)、T-钙黏蛋白(T-cad)与急性胰腺炎(AP)患者病情严重程度、疾病转归的关系。 方法选取88例AP患者,按病情严重程度分为轻症组和重症组,按照预后分为预后不良组和预后良好组；另选取健康体检者60例为对照组。比较各组血清8-OHdG、T-cad水平和Ranson评分。分析血清8-OHdG、T-cad与Ranson评分关系、血清8-OHdG和T-cad对AP预后的评估价值以及AP患者预后的影响因素。 结果8-OHdG水平和Ranson评分重症组＞轻症组＞对照组,预后不良组＞预后良好组；T-cad水平重症组＜轻症组＜对照组,预后不良组＜预后良好组(P＜0.05)。8-OHdG与Ranson评分呈正相关,T-cad与Ranson评分呈负相关(P＜0.05)。入院Ranson评分、8-OHdG、T-cad是AP患者预后的危险因素(P＜0.001)。血清8-OHdG、T-cad两者联合预测AP患者预后的效能最高(P＜0.05)。 结论急性胰腺炎患者血清8-OHdG和T-cad与疾病严重程度及预后有关,有望作为预测急性胰腺炎患者预后的生物学指标。 |
| 英文摘要: |
| AimTo investigate the relationship between serum 8-hydroxydeoxyguanosine (8-OHdG), T-cadherin (T-cad) and the severity and prognosis of patients with acute pancreatitis (AP). MethodsA total of 88 patients with AP were selected and divided into mild disease group and severe disease group according to the severity of the disease. They were also divided into poor prognosis group and good prognosis group according to the prognosis. In addition, 60 healthy people were selected as the control group. The serum levels of 8-OHdG and T-cad and Ranson score were compared. The relationship between serum 8-OHdG, T-cad and Ranson score, the prognostic value of serum 8-OHdG and T-cad in patients with AP, as well as the influencing factors of prognosis in patients with AP, were analyzed. ResultsThe level of 8-OHdG and Ranson score was in an order of severe group＞mild group＞control group, and the poor prognosis was in an order of group＞good prognosis group. The order of T-cad level was severe group＜mild group＜control group, and poor prognosis group＜good prognosis group (P＜0.05). 8-OHdG was positively correlated with Ranson score, while T-cad was negatively correlated with Ranson score (P＜0.05). Admission Ranson score, 8-OHdG and T-cad were risk factors for the prognosis of AP patients (P＜0.001). The combination of serum 8-OHdG and T-cad had the highest efficacy in predicting the prognosis of patients with AP (P＜0.05). ConclusionSerum 8-OHdG and T-cad in patients with acute pancreatitis are related to disease severity and prognosis, and are expected to be used as biological indicators to predict the prognosis of patients with acute pancreatitis. |
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