| 李双良,陶艳,何蓉会,张昌艳.不同病情程度肺结核患者血清α1-酸性糖蛋白和β干扰素的差异表达及其对疗效的预测.[J].中南医学科学杂志.,2024,(4):582-584. |
| 不同病情程度肺结核患者血清α1-酸性糖蛋白和β干扰素的差异表达及其对疗效的预测 |
| Differential expression of serum α1-acid glycoprotein and interferon-β in patients with pulmonary tuberculosis of different severity and its value for the prediction of therapeutic effect |
| 投稿时间：2023-06-26 修订日期：2024-05-20 |
| DOI：10.15972/j.cnki.43-1509/r.2024.04.018 |
| 中文关键词: 肺结核 AAG IFN-β 联合检测 |
| 英文关键词:tuberculosis AAG IFN-β combined detection |
| 基金项目:四川省基层卫生事业发展研究中心项目(SWFZ2022-Y-17) |
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| 中文摘要: |
| 目的探究不同病情程度肺结核患者血清α1-酸性糖蛋白(AAG)和β干扰素(IFN-β)的差异表达及其对疗效的预测。 方法选取120例肺结核患者为研究组,根据病情分为稳定期组和活动期组；根据治疗效果分为无效组和有效组。另选取同期进行治疗的普通肺炎患者120例为对照组。比较各组患者血清AAG和IFN-β水平。诊断试验和ROC分析检测AAG和INF-β对肺结核疗效的预测价值。 结果血清AAG、IFN-β水平研究组低于对照组,活动期组低于稳定期组,无效组低于有效组(P＜0.05)。联合诊断效能分析显示,血清AAG和IFN-β联合检测对疗效预测的灵敏度显著高于单独检测。ROC分析结果显示,血清AAG和IFN-β联合检测对疗效预测的曲线下面积显著高于单独检测。 结论不同病情程度肺结核患者血清AAG和IFN-β呈现显著差异,血清AAG和IFN-β联合检测对患者疗效具有良好预测价值。 |
| 英文摘要: |
| AimTo explore the differential expression of serum α1-acid glycoprotein (AAG) and interferon-β (IFN-β) in patients with pulmonary tuberculosis of different disease degrees and the value for the prediction of therapeutic effect. Methods120 patients with pulmonary tuberculosis were selected as the study group, and divided into stable phase group and active phase group based on their condition, or divide into ineffective group and effective group based on treatment effectiveness. Another 120 patients with common pneumonia who underwent treatment at the same time were selected as the control group. The different levels of serum AAG and IFN-β of patients in each group were compared. The diagnostic tests and ROC analysis were used to analyze the predictive value of the detection indicators for the therapeutic efficacy of pulmonary tuberculosis. ResultsSerum AAG and IFN-β in the study group was lower than the control group, the active period group was lower than the stable period group, and the ineffective group was lower than the effective group (P＜0.05). Joint diagnostic efficacy analysis showed that joint testing for serum AAG and IFN-β had significantly higher predictive sensitivity compared with single testing. The ROC curve analysis results showed that joint detection of serum AAG and IFN-β had significantly larger area under the curve for efficacy prediction compared with single testing. ConclusionSerum AAG and IFN-β levels showed significant differences in patients with pulmonary tuberculosis of different severity, and joint testing of serum AAG and IFN-β levels has good predictive value for patient therapeutic effects. |
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