| 蒙绪海.γ干扰素基因DNA甲基化水平与儿童乙型肝炎疫苗无/低免疫的关系.[J].中南医学科学杂志.,2024,(3):477-479. |
| γ干扰素基因DNA甲基化水平与儿童乙型肝炎疫苗无/低免疫的关系 |
| Relationship between DNA methylation level of interferon-γ gene and no/low immunity to hepatitis B vaccine in children |
| 投稿时间：2023-06-30 修订日期：2023-10-26 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.042 |
| 中文关键词: γ干扰素基因 DNA甲基化 儿童 乙型肝炎 免疫应答 [ |
| 英文关键词:interferon-γ gene DNA methylation children hepatitis B immune response |
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| 中文摘要: |
| 目的探讨γ干扰素(IFN-γ)基因DNA甲基化水平与儿童乙型肝炎疫苗无/低免疫的关系。 方法选取214名8~9月龄儿童,均完成0、1、6月乙型肝炎疫苗接种。根据HBsAb水平分为无/低应答组、正常/高应答组,比较两组IFN-γ基因10个CpG位点DNA甲基化水平,并分析其与乙型肝炎疫苗无/低免疫反应的关系。 结果214例儿童中无应答6例、低应答81例、正常应答52例、高应答75例。无/低应答组IFN-γ基因44和93位点甲基化水平高于正常/高应答组(P＜0.05)。Logistic回归分析显示,IFN-γ基因44位点[OR＝1.320(1.031,1.934)]和93位点[OR＝1.480(1.146,2.374)]高甲基化水平是儿童乙型肝炎疫苗无/低应答的危险因素(P＜0.05)。 结论IFN-γ基因44和93位点的DNA甲基化水平是儿童乙型肝炎疫苗无/低免疫反应的危险因素。 |
| 英文摘要: |
| AimTo investigate the relationship between DNA methylation level of interferon γ (IFN-γ) gene and no/low immunity of hepatitis B vaccine in children. MethodsA total of 214 children aged 8－9 months with hepatitis B vaccination completed in 0,1 and 6 months were selected. According to the level of HBsAb, they were divided into no/low response group and normal/high response group. The methylation levels of 10 CpG site of the IFN-γ gene in the two groups were compared, and its association with no/low immune response to hepatitis B vaccine was analyzed. ResultsOf the 214 children, 6 were non-responders, 81 were low responders, 52 were normal responders, and 75 were high responders. The methylation levels of IFN-γ gene at sites of 44 and 93 in the non-/low-response group were higher than those in the normal/high-response group (P＜0.05). Logistic regression analysis showed that the high hypermethylation levels of IFN-γ gene at loci of 44 [OR＝1.320(1.031,1.934)] and 93 [OR＝1.480 (1.146,2.374)] were child-related risk factors for no/low response to hepatitis B vaccine (P＜0.05). ConclusionThe DNA methylation levels of IFN-γ gene at site of 44 and 93 are risk factors for no/low immune response to hepatitis B vaccine in children. |
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