| 符学兴,许峻,李可毕.NT-proBNP、IFN-γ、NO在重症手足口病诊断及预后评估中的价值.[J].中南医学科学杂志.,2024,(3):467-470. |
| NT-proBNP、IFN-γ、NO在重症手足口病诊断及预后评估中的价值 |
| Value of NT-proBNP, IFN-γ and NO in the diagnosis and prognosis evaluation of severe hand-foot-mouth disease |
| 投稿时间：2023-03-13 修订日期：2024-02-25 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.039 |
| 中文关键词: 手足口病 重症 NT-proBNP IFN-γ NO 预后评估 [ |
| 英文关键词:hand-foot-mouth disease severe NT-proBNP IFN-γ NO prognosis evaluation |
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| 中文摘要: |
| 目的探讨氨基末端脑钠肽前体(NT-proBNP)、γ干扰素(IFN-γ)、一氧化氮(NO)在重症手足口病诊断和预后评估中的应用价值。 方法选取手足口病患儿224例,根据病情分为轻症组和重症组,另选取同期健康儿童30例为对照组；重症组根据预后分为生存组和死亡组。比较各组血清NT-proBNP、IFN-γ、NO水平。采用ROC分析NT-proBNP、IFN-γ、NO对重症手足口病诊断和预后的预测价值。采用Logistic回归分析重症手足口病患儿预后的影响因素。 结果重症组、轻症组、对照组血清NT-proBNP、IFN-γ、NO依次降低；死亡组血清NT-proBNP、IFN-γ、NO高于生存组(P＜0.05)。死亡组血氧饱和度＜90%者死亡率高于血氧饱和度≥90%者。血清NT-proBNP、IFN-γ、NO联合检测对重症手足口病诊断和预后均具有良好的预测价值(P＜0.05)。血清NT-proBNP、IFN-γ、NO高表达是重症手足口病患儿不良预后的危险因素,血氧饱和度＜90%是预后良好的保护因素。 结论重症手足口病患儿血清NT-proBNP、IFN-γ、NO水平升高,联合检测对其诊断和预后评估具有重要价值。 |
| 英文摘要: |
| AimTo explore the application value of N-terminal pro-brain natriuretic peptide (NT-proBNP), interferon-γ (IFN-γ) and nitric oxide (NO) in the diagnosis and prognosis evaluation of severe hand-foot-mouth disease. MethodsA total of 224 children with hand-foot-mouth disease were enrolled. According to disease severity, they were divided into mild group and severe group. A total of 30 healthy children during the same period were enrolled as control group. According to prognosis results, children in severe group were divided into survival group and death group. The levels of serum NT-proBNP, IFN-γ and NO in different groups were compared. The value of NT-proBNP, IFN-γ and NO in the diagnosis and prognosis prediction of severe hand-foot-mouth disease was analyzed by ROC curves. Using Logistic regression to analyze the influencing factors of prognosis for severe hand, foot, and mouth disease. ResultsThe levels of serum NT-proBNP, IFN-γ and NO were gradually decreased in severe group, mild group and control group. The levels of serum NT-proBNP, IFN-γ and NO in death group were higher than those in survival group (P＜0.05). In death group, death rate in patients with oxygen saturation ＜90% was higher than that of patients with oxygen saturation ≥90%. The combined detection of serum NT-proBNP, IFN-γ and NO was of good value in the diagnosis and prognosis prediction of severe hand-foot-mouth disease (P＜0.05). The high expressions of serum NT-proBNP, IFN-γ and NO are risk factors of poor prognosis in children with severe HFMD, while oxygen saturation ＜90% was a protective factor of good prognosis. ConclusionThe levels of serum NT-proBNP, IFN-γ and NO are increased in children with severe HFMD, and combined detection of the three indexes is of great value in the diagnosis and prognosis evaluation of HFMD. |
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