| 蒋红梅,陈琴,王蓓蓓.CLCA2的表达与宫颈癌临床病理特征及预后的关系.[J].中南医学科学杂志.,2024,(3):463-466. |
| CLCA2的表达与宫颈癌临床病理特征及预后的关系 |
| Relationship between CLCA2 expression and clinicopathologic features as well as prognosis of cervical cancer |
| 投稿时间：2023-05-07 修订日期：2023-11-18 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.038 |
| 中文关键词: 宫颈癌 钙激活性氯离子通道2 临床病理特征 预后 [ |
| 英文关键词:cervical cancer calcium-activated chloride channel 2 clinicopathological features prognosis |
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| 中文摘要: |
| 目的探究宫颈癌组织中钙激活性氯离子通道2(CLCA2)的表达与患者临床病理特征及预后的关系。 方法收集97例宫颈癌患者临床资料,分析其癌组织及癌旁组织CLCA2表达情况,以及癌组织中CLCA2表达与临床病理特征的关系；随访3年,采用生存分析、Cox回归分析法探究CLCA2表达与预后的关系。 结果宫颈癌组织中CLCA2阴性表达率高于癌旁组织(P＜0.05)；CLCA2阴性组患者BMI≥30 kg/m2、淋巴结转移、低分化程度及＞1/2肌层浸润程度患者占比高于CLCA2阳性组(P＜0.05)；CLCA2阴性、阳性患者3年累计存活率差异存在显著性(P＜0.05)；Cox分析显示,宫颈癌TNM Ⅲ期、淋巴结转移、＞1/2肌层浸润及CLCA2阴性是影响宫颈癌预后的独立危险因素(P＜0.05)。 结论宫颈癌组织中CLCA2下调,CLCA2表达与BMI、淋巴结转移、浸润程度及预后情况均相关,且高表达患者预后更好。 |
| 英文摘要: |
| AimTo investigate the relationship between the expression of calcium-activated chloride channel 2 (CLCA2) and clinicopathologic features as well as prognosis of cervical cancer. MethodsClinical data of 97 patients with cervical cancer were collected to analyze the expression of CLCA2 in cancer and adjacent tissues and the relationship between CLCA2 expression and clinicopathological features. The patients were followed-up for 3 years, and the relationship between CLCA2 expression and prognosis was explored by using survival analysis and Cox regression analysis. ResultsThe negative expression rate of CLCA2 in cervical cancer tissues was higher than that in adjacent tissues (P＜0.05). The proportion of patients with BMI≥30 kg/m2, lymph node metastasis, low differentiation degree and ＞1/2 muscle infiltration degree in CLCA2-negative group was higher than that in CLCA2-positive group (P＜0.05). There was a difference in the 3-year cumulative survival rate between the two patients (P＜0.05). Cox analysis showed that TNM stage Ⅲ, lymph node metastasis, ＞1/2 muscle infiltration and CLCA2 negative were independent risk factors for cervical cancer prognosis (P＜0.05). ConclusionCLCA2 is downregulated in cervical cancer tissue, and the expression of CLCA2 is correlated with BMI, lymph node metastasis, degree of invasion and prognosis. The patients with high expression have better prognosis. |
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