| 王丹,张洁,刘辉勇.EGFR、PRDX4、GLUT-1在口腔鳞癌组织中的表达水平及其临床意义.[J].中南医学科学杂志.,2024,(3):456-459. |
| EGFR、PRDX4、GLUT-1在口腔鳞癌组织中的表达水平及其临床意义 |
| Expression levels and clinical significance of EGFR, PRDX4 and GLUT-1 in oral squamous cell carcinoma tissues |
| 投稿时间：2023-04-18 修订日期：2024-02-26 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.036 |
| 中文关键词: EGFR PRDX4 GLUT-1 口腔鳞癌 [ |
| 英文关键词:EGFR PRDX4 GLUT-1 oral squamous cell carcinoma |
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| 中文摘要: |
| 目的研究表皮生长因子受体(EGFR)、过氧化物还原蛋白4(PRDX4)、葡萄糖转运蛋白-1(GLUT-1)在口腔鳞癌(OSCC)组织中的表达水平及其临床意义。 方法选取口腔鳞癌患者74例,比较其癌组织和癌旁正常组织EGFR、PRDX4、GLUT-1 mRNA和蛋白表达情况,分析三者表达水平的相关性,以及其与OSCC病理特征、患者生存时间的关系。 结果OSCC癌组织中EGFR、PRDX4、GLUT-1 mRNA水平及蛋白阳性表达率高于癌旁正常组织(P＜0.05)。OSCC患者组织EGFR、PRDX4、GLUT-1表达水平互相呈正相关(P＜0.001)。低分化程度、有淋巴结转移、Ⅲ期~Ⅳ期患者EGFR、PRDX4和GLUT-1阳性表达率较高(P＜0.05)。EGFR、PRDX4、GLUT-1阳性表达者总生存率低于阴性表达者(P＜0.05)。 结论OSCC癌组织EGFR、PRDX4、GLUT-1表达水平明显升高,且与临床病理参数及生存时间紧密相关,可能参与OSCC的发生发展。 |
| 英文摘要: |
| AimTo study the expression levels and clinical significance of epidermal growth factor receptor (EGFR), peroxiredoxin 4 (PRDX4) and glucose transporter-1 (GLUT-1) in oral squamous cell carcinoma tissues. Methods74 patients with oral squamous cell carcinoma (OSCC) were selected. The mRNA and protein expression levels of EGFR, PRDX4 and GLUT-1 in cancer tissues and adjacent normal tissues were compared, and the correlation among the expression levels of the three indicators as well as the relationship with pathological characteristics and survival time of OSCC patients were analyzed. ResultsThe mRNA expression and protein positive expression rate levels of EGFR, PRDX4 and GLUT-1 in OSCC cancer tissues were higher than those in adjacent normal tissues (P＜0.05). The expression levels of EGFR, PRDX4, and GLUT-1 in OSCC tissues were positively correlated with each other (P＜0.001). The positive expression rates of EGFR, PRDX4 and GLUT-1 were higher in patients with low differentiation degree, lymph node metastasis and stage Ⅲ －Ⅳ (P＜0.05). The overall survival rate of patients with positive expressions of EGFR, PRDX4 and GLUT-1 was significantly lower than that of patients with negative expressions (P＜0.05). ConclusionThe expression levels of EGFR, PRDX4 and GLUT-1 in OSCC tissues are significantly increased, and are closely related to clinicopathological parameters and survival time of patients, which may be involved in the occurrence and development of OSCC. |
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