| 肖娜娜,闫学爽,张彩宁,王丹,陈源,李娅.不同胎龄早产儿凝血功能比较及颅内出血影响因素分析.[J].中南医学科学杂志.,2024,(3):446-448. |
| 不同胎龄早产儿凝血功能比较及颅内出血影响因素分析 |
| Comparison of coagulation function in premature infants of different gestational ages and analysis of factors to influence intracranial hemorrhage |
| 投稿时间：2023-07-05 修订日期：2024-03-28 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.033 |
| 中文关键词: 胎龄 早产儿 凝血功能 颅内出血 影响因素 [ |
| 英文关键词:gestational age premature baby coagulation function intracranial hemorrhage influencing factor |
| 基金项目:保定市科学技术项目(2241ZF199) |
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| 中文摘要: |
| 目的分析不同胎龄早产儿凝血功能及颅内出血影响因素。 方法选择500例早产儿纳入早产儿组,根据胎龄分为早期早产儿组和晚期早产儿组；根据是否颅内出血分为出血组和未出血组。同期选择足月健康新生儿250例为对照组。比较各组血浆凝血酶原时间(PT)、血浆纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、D-二聚体(DD)、颅内出血发生率。采用多因素Logistic回归分析早产儿出现颅内出血的影响因素。 结果早期早产儿组、晚期早产儿组PT、APTT、DD、颅内出血发生率高于对照组,FIB低于对照组,且早期早产儿组较晚期早产儿组更为显著(P＜0.05)。出血组早产儿5 min Apgar评分、胎龄、出生体质量、FIB低于未出血组,胎内窘迫、PS治疗、机械通气占比、PT、APTT高于未出血组(P＜0.05)。胎内窘迫、PS治疗、机械通气占比、PT、APTT、5 min Apgar评分、胎龄、出生体质量、FIB均为颅内出血影响因素(P＜0.05)。 结论早产儿多出现凝血功能紊乱,其颅内出血的影响因素较多,早期干预有助于降低早产儿颅内出血发生率。 |
| 英文摘要: |
| AimTo analyze the factors to influence coagulation function and intracranial hemorrhage in premature infants of different gestational ages. Methods500 premature infants were selected and divided into early premature infants and late premature infants according to gestational age. According to whether there is intracranial hemorrhage or not, they were divided into bleeding group and non-bleeding group. At the same time, 250 full-term healthy newborns were selected as the control group. Plasma prothrombin time (PT), plasma fibrinogen (FIB), activated partial thromboplastin time (APTT), D- dimer (DD) and incidence of intracranial hemorrhage were compared among the groups. Multivariate Logistic regression was used to analyze the factors influencing intracranial hemorrhage in premature infants. ResultsThe incidence of PT, APTT, DD and intracranial hemorrhage in early premature infants and late premature infants was higher than that in the control group, while FIB was lower than that in the control group, and the incidence in early premature infants was more significant than that in late premature infants (P＜0.05). The 5-minute Apgar score, gestational age, birth weight and FIB of premature infants in bleeding group were lower than those in non-bleeding group, while the fetal distress, PS therapy, mechanical ventilation rate, PT and APTT were higher than those in non-bleeding group (P＜0.05). Fetal distress, PS therapy, mechanical ventilation, PT, APTT, 5 min Apgar score, gestational age, birth weight and FIB were all factors influencing intracranial hemorrhage (P＜0.05). ConclusionPremature infants often have coagulation dysfunction, and there are many factors to influence intracranial hemorrhage. Early intervention is helpful to reduce the incidence of intracranial hemorrhage in premature infants. |
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