| 郝永欣,孟祥安,骆允,刘欢,刘磊.超声血流成像、超声造影对结直肠癌的诊断价值及其与病灶微血管密度的相关性.[J].中南医学科学杂志.,2024,(3):424-427. |
| 超声血流成像、超声造影对结直肠癌的诊断价值及其与病灶微血管密度的相关性 |
| The diagnostic value of ultrasound blood flow imaging and contrast enhanced ultrasound in colorectal cancer and their correlation with microvessel density of lesions |
| 投稿时间：2023-05-11 修订日期：2024-02-20 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.027 |
| 中文关键词: 结直肠癌 超声血流成像 超声造影 微血管密度 血流动力学 [ |
| 英文关键词:colorectal cancer ultrasonic blood flow imaging contrast enhanced ultrasound microvessel density hemodynamics |
| 基金项目:廊坊市科学技术局项目(2022013121) |
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| 中文摘要: |
| 目的探讨超声血流成像、超声造影(CEUS)对结直肠癌的诊断价值及其与病灶微血管密度(MVD)的相关性。 方法选取107例结直肠肿瘤患者,按病理结果分为恶性组(按分期分亚组)和良性组。比较各组超声血流成像指标动脉收缩期峰值流速(PSV)、阻力指数(RI)、舒张期末流速(EDV)和CEUS指标峰值强度(PI)、达峰时间(TTP)、曲线下面积(AUC)、上升斜率(A),比较不同分期组MVD；分析恶性组超声血流成像、CEUS指标与MVD的相关性,以及超声血流成像、CEUS对结直肠癌的诊断价值。 结果超声血流成像、CEUS联合检查准确率高于单独检测(P＜0.05)。恶性组PSV、EDV高于良性组,RI低于良性组；PI、TTP低于良性组,AUC、A高于良性组(P＜0.05)。Ⅳ期组PSV、EDV及MVD高于Ⅰ~Ⅲ期组,RI低于Ⅰ~Ⅲ期组；Ⅱ~Ⅳ期组PI、TTP低于Ⅰ期组,AUC及A高于Ⅰ期组(P＜0.05)。恶性组PI、RI分别与MVD呈负相关,AUC、PSV分别与MVD呈正相关(P＜0.05)。超声血流成像联合CEUS检测对结直肠癌诊断效能高于单独检测(P＜0.001)。 结论超声血流成像联合CEUS对结直肠癌的诊断效果优于单独检测,可反映结直肠癌微循环血流灌注状态,为结直肠癌临床治疗方案提供参考。 |
| 英文摘要: |
| AimTo investigate the diagnostic value of ultrasound blood flow imaging and contrast enhanced ultrasound (CEUS) in colorectal cancer and its correlation with microvessel density (MVD) of lesions. Methods107 patients with colorectal cancer were selected and divided into malignant group (subgroups according to stage) and benign group according to the pathological results. The peak systolic velocity (PSV), resistance index (RI), end diastolic velocity (EDV), peak intensity (PI), time to peak (TTP), area under the curve (AUC), and Slope rate of ascending curve (A) of CEUS were compared among the three groups.The correlation of ultrasound blood flow imaging, CEUS index and MVD in malignant group was analyzed. The diagnostic value of ultrasound blood flow imaging and CEUS in colorectal cancer was analyzed. ResultsThe accuracy of ultrasound blood flow imaging combined with CEUS was higher than that of single detection (P＜0.05). PSV and EDV in malignant group were higher than those in benign group, and RI was lower than that in benign group. PI and TTP were lower than those in benign group, while AUC and A were higher than those in benign group (P＜0.05). PSV, EDV and MVD in stage IV group were higher than those in stage Ⅰ－Ⅲ group, and RI was lower than that in stage Ⅰ－Ⅲ group.PI and TTP in stage Ⅱ－Ⅳ group were lower than those in stage Ⅰ group, while AUC and A were higher than those in stage Ⅰ group (P＜0.05). In malignant group, PI and RI were negatively correlated with MVD, while AUC and PSV were positively correlated with MVD (P＜0.05). The diagnostic efficiency of ultrasound blood flow imaging combined with CEUS in colorectal cancer was higher than that of single detection (P＜0.001). ConclusionThe diagnostic efficacy of ultrasound blood flow imaging combined with CEUS for colorectal cancer is better than that of single detection, which can reflect the microcirculation blood flow perfusion state of colorectal cancer, and provide reference for clinical treatment of colorectal cancer. |
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