| 彭丽琨,何大可,张翠香,杨巨品,严家威,董宇莹,江泳,黄张杨,段丽梅.中枢性性早熟儿童25-羟基维生素D3、神经肽吻素与血清P1NP和N-MID OC的相关性.[J].中南医学科学杂志.,2024,(3):418-420. |
| 中枢性性早熟儿童25-羟基维生素D3、神经肽吻素与血清P1NP和N-MID OC的相关性 |
| The correlation between 25-hydroxyvitamin D, kisspeptin and serum P1NP and N-MID OC in children with central precocious puberty |
| 投稿时间：2023-02-19 修订日期：2023-06-14 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.025 |
| 中文关键词: 中枢性性早熟 骨代谢 25-羟基维生素D3 Kisspeptin P1NP N-MID OC [ |
| 英文关键词:central precocious puberty bone metabolism 25-hydroxyvitamin D3 Kisspeptin P1NP N-MID OC |
| 基金项目:云南省科技厅科技人才与平台计划(202005AD160013) |
| 作者 | 单位 | E-mail | | 彭丽琨 | 大理白族自治州人民医院儿科三病区,云南大理 671000 | e-mail为13508823352@163.com,e-mail为hedake@139.com | | 何大可 | 上海交通大学附属新华儿童医院小儿神经内科,上海 200127 | e-mail为13508823352@163.com,e-mail为hedake@139.com | | 张翠香 | 大理白族自治州人民医院儿科三病区,云南大理 671000 | | | 杨巨品 | 大理白族自治州人民医院儿科三病区,云南大理 671000 | | | 严家威 | 大理白族自治州人民医院儿科三病区,云南大理 671000 | | | 董宇莹 | 大理白族自治州人民医院儿科三病区,云南大理 671000 | | | 江泳 | 大理白族自治州人民医院儿科三病区,云南大理 671000 | | | 黄张杨 | 大理白族自治州人民医院儿科三病区,云南大理 671000 | | | 段丽梅 | 大理白族自治州人民医院儿科三病区,云南大理 671000 | |
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| 中文摘要: |
| 目的分析25-羟基维生素D3[25-(OH)D3]水平、神经肽吻素(Kisspeptin)在中枢性性早熟(CPP)儿童中的表达,及其与血清Ⅰ型前胶原氨基端延长肽(P1NP)、N端中段骨钙素(N-MID OC)的相关性。 方法86例CPP患儿作为CPP组,同时选取50例单纯性乳房早发育(PT)及50例体检正常的健康儿童,分别作为PT组和健康组。对比各组血清25-(OH)D3、Kisspeptin、P1NP及N-MID OC水平,采用Pearson相关性分析血清25-(OH)D3、Kisspeptin与P1NP和N-MID OC的相关性。 结果CPP组25-(OH)D3水平低于PT组和健康组,PT组25-(OH)D3水平低于健康组(P＜0.05)；CPP组Kisspeptin、P1NP及N-MID OC水平高于PT组和健康组,PT组Kisspeptin、P1NP及N-MID OC水平高于健康组(P＜0.05)。25-(OH)D3与血清P1NP及N-MID OC呈负相关(r=－0.259、－0.323,P＜0.05)。Kisspeptin与血清P1NP及N-MID OC呈正相关(r=0.426、0.610,P＜0.05)。 结论CPP患儿表现为25-(OH)D3低水平和Kisspeptin高水平,且患儿25-(OH)D3和Kisspeptin水平与骨代谢标志物P1NP及N-MID OC呈显著相关性,可作为评估CPP患儿骨代谢情况的参考指标。 |
| 英文摘要: |
| AimTo analyze the level of 25-hydroxyvitamin D3 (25-(OH)D3) and the expression of neuropeptide Kisspeptin in children with central precocious puberty (CPP) and its correlation with serum procollagen type Ⅰ n-terminal pro peptide (P1NP) and n-mido osteocalcin (N-MID Osteocalcin, N-MID OC). MethodsA total of 86 cases of CPP children were selected as CPP group, and at the same time, 50 cases of simple early breast development (PT) and 50 cases of healthy children with normal physical examination were selected as the PT group and the healthy group, respectively. The serum 25-(OH)D3, Kisspeptin and P1NP, and N-MID OC levels in each group were compared, and the correlations between serum 25-(OH)D3, Kisspeptin and P1NP, N-MID OC were analyzed by Pearson correlation. The scatter plots were drawn. ResultsThe levels of 25-(OH)D3 in the CPP group were lower than those in the PT group and the health group, and the levels of 25-(OH)D3 in the PT group were lower than those in the health group (P＜0.05). The levels of Kisspeptin, P1NP and N-MID OC in the CPP group were higher than those in the PT group and the health group, and the levels of Kisspeptin, P1NP and N-MID OC in the PT group were higher than those in the health group (P＜0.05). 25-(OH)D3 was negatively correlated with serum P1NP and N-MID OC (r＝－0.259, －0.323, P＜0.05). Kisspeptin was positively correlated with serum P1NP and N-MID OC (r＝0.426,0.610, P＜0.05). ConclusionChildren with CPP show low levels of 25-(OH)D3 and high levels of Kisspeptin, and the levels of 25-(OH)D3 and Kisspeptin in children with CPP have a significant correlation with bone metabolism markers P1NP and N-MID OC, which can be used as reference indicators to evaluate bone metabolism in children with CPP. |
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