| 高婷婷,梁超,任涛涛.TLR7基因多态性与儿童手足口病易感性及严重程度的关系.[J].中南医学科学杂志.,2024,(3):403-406. |
| TLR7基因多态性与儿童手足口病易感性及严重程度的关系 |
| Relationship between polymorphisms of TLR7 gene and susceptibility and severity of hand-foot-mouth disease in children |
| 投稿时间：2023-09-21 修订日期：2024-02-15 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.021 |
| 中文关键词: 手足口病 易感性 严重程度 TLR7 基因多态性 [ |
| 英文关键词:hand-foot-mouth disease susceptibility severity Toll-like receptor 7 gene polymorphism |
| 基金项目:青岛市中医药科研计划项目(2019-zyy020) |
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| 中文摘要: |
| 目的探讨Toll样受体7(TLR7)基因多态性与儿童手足口病(HFMD)易感性及严重程度的关系。 方法选取304例肠道病毒71型(EV71)感染HFMD患儿纳入HFMD组,根据病情严重程度分为轻症组和重症组；另同期选择300例正常健康儿童纳入对照组。比较各组TLR7基因rs3853839、rs179016、rs179009位点基因型和基因频率。Logistic回归分析基因多态性是否HFMD发生的危险因素,比较与否携带C基因患儿的外周血单个核细胞TLR7 mRNA表达水平。 结果HFMD组、重症组女童、男童TLR7基因rs3853839位点、rs179016位点C基因型及基因频率分别高于对照组、轻症组(P＜0.05)。TLR7基因rs3853839位点、rs179016位点携带C基因是儿童HFMD发生和重症的危险因素(P＜0.05)。HFMD轻症和重症患儿rs3853839位点、rs179016位点携带C基因者外周血单个核细胞TLR7 mRNA表达水平均低于未携带C基因者(P＜0.05)。 结论TLR7基因rs3853839位点、rs179016位点携带C基因是儿童HFMD发生的独立危险因素,且与其严重性相关。 |
| 英文摘要: |
| AimTo explore the relationship between polymorphisms of Toll-like receptor 7 (TLR7) gene and susceptibility and severity of hand-foot-mouth disease (HFMD) in children. MethodsA total of 304 children with enterovirus 71 (EV71) infection and HFMD were enrolled as HFMD group. According to disease severity, they were divided into mild group and severe group. A total of 300 healthy children during the same period were enrolled as control group. The genotypes and gene frequencies of TLR7 gene at rs3853839, rs179016 and rs179009 loci in different groups were compared. Whether gene polymorphisms could be risk factors of HFMD was determined by Logistic regression analysis. The mRNA level of TLR7 in peripheral blood mononuclear cells in children with or without C gene was compared. ResultsThe frequencies of girls' and boys' C genotype in TLR7 gene at rs3853839 and rs179016 loci in HFMD group and severe group were higher than those in control group and mild group (P＜0.05). C genotype of TLR7 gene at rs3853839 and rs179016 loci was a risk genotype of HFMD and serious illness (P＜0.05). The expression level of TLR7 mRNA in mild and severe HFMD children with C genotype at rs3853839 and rs179016 loci was lower than that in children without C genotype (P＜0.05). ConclusionC genotype of TLR7 gene at rs3853839 and rs179016 loci is an independent risk factor for HFMD in children, which is correlated with the disease severity. |
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