| 唐雷,周铁,李嘉诚,陆晓俊.盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者血清免疫和炎症指标的影响.[J].中南医学科学杂志.,2024,(3):396-399. |
| 盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者血清免疫和炎症指标的影响 |
| Effects of triple-therapy of tamsulosin hydrochloride, qianlie beixi and acupuncture on serum immune and inflammatory indexes in patients with type Ⅲ B chronic prostatitis |
| 投稿时间：2023-10-14 修订日期：2024-04-17 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.019 |
| 中文关键词: 慢性前列腺炎 盐酸坦索罗辛 前列倍喜 针灸 免疫 炎症 [ |
| 英文关键词:chronic prostatitis tamsulosin hydrochloride qianlie beixi acupuncture immune inflammation |
| 基金项目:上海市虹口区卫生健康委员会中医药科课题(HKQGYQY-ZYY-2022-19) |
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| 中文摘要: |
| 目的探究盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者血清免疫和炎症指标的影响。 方法选取ⅢB型慢性前列腺炎患者120例,随机均分为对照组(盐酸坦索罗辛+前列倍喜)及三联组(盐酸坦索罗辛+前列倍喜+针灸)。比较两组临床疗效、治疗前后中医证候评分、美国国立卫生研究院慢性前列腺炎症指数(NIH-CPSI)评分、血清免疫指标[免疫球蛋白(Ig)A、IgM、IgG]和炎症指标[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-2、IL-8、IL-10]水平。 结果治疗后,三联组治疗总有效率高于对照组(P＜0.05)。与治疗前比较,治疗后两组中医证候评分、NIH-CPSI评分、TNF-α、IL-2及IL-8降低,IgA、IgM、IgG升高,且三联组较对照组更为显著(P＜0.05)。与治疗前比较,治疗后两组IL-10升高(P＜0.05),但两组间比较差异无显著性(P＞0.05)。 结论盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者临床疗效显著,可明显改善其血清免疫和炎症指标。 |
| 英文摘要: |
| AimTo investigate the effects of triple-therapy of tamsulosin hydrochloride, qianlie beixi and acupuncture on serum immune and inflammatory indexes in patients with type Ⅲ B chronic prostatitis. MethodsOne hundred and twenty patients with type Ⅲ B chronic prostatitis were selected and randomly divided into the control group (tamsulosin hydrochloride + qianlie beixi) and the triple-therapy group (tamsulosin hydrochloride + qianlie beixi + acupuncture). The two groups were compared in terms of clinical efficacy, TCM syndrome scores, the national institute of health-chronic prostatitis symptom index (NIH-CPSI) score, and the levels of serum immune indexes (immunoglobulin (Ig) A, IgM and IgG) and inflammatory indexes (tumor necrosis factor-α (TNF-α), interleukin-2, IL-8 and IL-10). ResultsAfter treatment, total effective rate in the triple therapy group was higher than that in the control group (P＜0.05). After treatment, there were decreases in TCM syndrome scores, NIH-CPSI scores, TNF-α, IL-2 and IL-8, and increases in IgA, IgM and IgG in both groups, and these effects were more obvious in the triple therapy group in comparison with control group (P＜0.05). After treatment, there were increases in IL-10 levels in both groups (P＜0.05), but there was no significant difference between the groups (P＞0.05). ConclusionThe triple-therapy of tamsulosin hydrochloride, qianlie beixi and acupuncture is effective to treat patients with type Ⅲ B chronic prostatitis, which can significantly improve serum immune and inflammatory indexes. |
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