| 吴燕林,马君,杜延芬,王跃臻,段建颖,李丹.糖尿病周围神经病变足底压力变化及其与神经传导、感觉电流阈值和炎症因子的关系.[J].中南医学科学杂志.,2024,(3):388-391, 435. |
| 糖尿病周围神经病变足底压力变化及其与神经传导、感觉电流阈值和炎症因子的关系 |
| Plantar pressure changes in diabetic peripheral neuropathy and its relationship with nerve conduction, sensory current thresholds and inflammatory factors |
| 投稿时间：2023-06-14 修订日期：2024-02-10 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.017 |
| 中文关键词: 糖尿病 DPN 足底压力 神经传导 感觉电流 炎症因子 [ |
| 英文关键词:diabetes mellitus DPN plantar pressure nerve conduction sensory currents inflammatory factors |
| 基金项目:河北省医学科学研究课题(20211120) |
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| 中文摘要: |
| 目的探究糖尿病周围神经病变(DPN)足底压力变化及其与神经传导、感觉电流阈值和炎症因子的关系。 方法纳入2型糖尿病合并DPN患者590例,按照是否患有糖尿病足分为对照组(未发生糖尿病足,n＝320)和观察组(糖尿病足,n＝270)。另纳入同期体检健康人群为空白组(n＝150)。比较各组空腹血糖(FBG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、血脂、足底不同区域峰值压力、运动/感觉神经传导速度(NCV)、感觉电流阈值(CPT)、炎症因子[白细胞介素(IL)-1β、IL-10、肿瘤坏死因子-α(TNF-α)和巨噬细胞炎性蛋白-1α(MIP-1α)]水平。分析足底压力变化与神经传导、感觉电流阈值和炎症因子的相关性。 结果空白组、对照组、观察组足底不同区域峰值压力、FBG、2 hPG、IL-1β、IL-10、TNF-α、MIP-1α、HbA1c、CPT水平依次升高,NCV依次降低(P＜0.05)。Pearson相关性分析显示,IL-1β、IL-10、NCV、CPT、TNF-α和MIP-1α与不同区域足底压力均呈正相关(P＜0.05)。 结论DPN患者足底峰值压力升高,与神经传导、感觉电流阈值和炎症因子密切相关,可为临床提供参考。 |
| 英文摘要: |
| AimTo investigate the plantar pressure changes in diabetic peripheral neuropathy (DPN) and its relationship with nerve conduction, sensory current thresholds and inflammatory factors. Methods590 cases with type 2 diabetes mellitus complicated with DPN were included and divided into a control group (no diabetic foot, n＝320) and an observation group (diabetic foot, n＝270) according to whether they had a diabetic foot or not. Another healthy population with physical examination at the same time was included as a blank group (n＝150). Fasting blood glucose (FBG), 2 h postprandial blood glucose (2 hPG), glycated hemoglobin (HbA1c), blood fat, peak pressures in different areas of the plantar foot, motor/sensory nerve conduction velocity (NCV), current sensory threshold (CPT), and levels of inflammatory factors [(interleukin-1β (IL-1β), IL-10, tumor necrosis factor-α (TNF-α) and macrophage inflammatory protein-1α (MIP-1α)] were compared in each group. The correlation of plantar pressure changes with nerve conduction, sensory current thresholds, and inflammatory factors was analyzed. ResultsPeak plantar pressure, FBG, 2 hPG, IL-1β, IL-10, TNF-α, MIP-1α, HbA1c and CPT levels in different regions of the plantar foot in the blank, control, and observation groups were sequentially increased, and NCV was sequentially decreased (P＜0.05). Pearson correlation analysis showed that IL-1β, IL-10, NCV, CPT, TNF-α and MIP-1α were positively correlated with plantar pressure in different areas of the plantar foot (P＜0.05). ConclusionElevated peak plantar pressures in patients with DPN are closely related with nerve conduction, sensory current thresholds, and inflammatory factors, and may provide a clinical reference. |
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