| 杨丽,柳春芳,王志恒.超声造影定量参数联合外周血单个核细胞miR-34a、miR-146a对PTC诊断和淋巴结转移的评估价值.[J].中南医学科学杂志.,2024,(3):376-379. |
| 超声造影定量参数联合外周血单个核细胞miR-34a、miR-146a对PTC诊断和淋巴结转移的评估价值 |
| Evaluation value of quantitative parameters of contrast-enhanced ultrasound combined with peripheral blood mononuclear cell miR-34a and miR-146a in the diagnosis and lymph node metastasis of PTC |
| 投稿时间：2023-12-06 修订日期：2024-03-28 |
| DOI：10.15972/j.cnki.43-1509/r.2024.03.014 |
| 中文关键词: 乳头状甲状腺癌 早期诊断 淋巴结转移 超声造影 外周血单个核细胞 miR-34a miR-146a [ |
| 英文关键词:PTC early diagnosis lymph node metastasis contrast-enhanced ultrasound PBMC miR-34a miR-144 |
| 基金项目:山西省卫生健康委科研课题计划项目(2020162) |
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| 中文摘要: |
| 目的探讨超声造影定量参数联合外周血单个核细胞(PBMC)miR-34a、miR-146a对乳头状甲状腺癌(PTC)诊断和淋巴结转移的评估价值。 方法选取104例PTC患者,根据病理诊断分为甲状腺癌组69例和良性组35例；根据是否发生淋巴结转移,将69例甲状腺癌患者分为未转移组33例和转移组36例。比较各组超声造影定量参数峰值强度(PI)、达峰时间(TTP)、平均通过时间(MTT)、曲线下面积(AUC)和PBMC中miR-34a、miR-146a水平。采用ROC分析超声造影参数联合PBMC miR-34a、miR-146a对PTC诊断和淋巴结转移的评估价值。 结果与良性组比较,甲状腺癌组超声造影定量参数及PBMC miR-34a水平均降低(P＜0.05),而miR-146a水平升高(P＜0.05)。与未转移组比较,淋巴结转移组PI、AUC、miR-146a水平升高(P＜0.05),而TTP、MTT、miR-34a水平降低(P＜0.05)。超声造影定量参数与PBMC miR-34a、miR-146a对PTC诊断和淋巴结转移的AUC均高于各项指标单独检测值(P＜0.05)。 结论联合应用超声造影定量参数与PBMC miR-34a、miR-146a指标检测能增强PTC早期诊断与淋巴结转移的评估效能。 |
| 英文摘要: |
| AimTo explore the diagnostic and lymph node metastasis evaluation value of contrast-enhanced ultrasound quantitative parameters combined with peripheral blood mononuclear cell (PBMC) miR-34a and miR-146a in papillary thyroid cancer (PTC). Methods104 patients with PTC in our hospital were selected and divided into a thyroid cancer group of 69 cases and a benign group of 35 cases based on surgical pathological diagnosis. Based on whether or not lymph nodes have metastasized, 69 thyroid cancer patients were divided into a non-metastatic group of 33 cases and a metastatic group of 36 cases. The peak intensity (PI), time to peak (TTP), mean transit time (MTT), area under curve (AUC), and levels of miR-34a and miR-146a in PBMC in different groups were compared. The evaluation value of contrast-enhanced ultrasound parameters combined with PBMC miR-34a and miR-146a in the diagnosis and lymph node metastasis of PTC was analyzed by using ROC curves. ResultsCompared with the benign group, the quantitative parameters and PBMC miR-34a levels in the thyroid cancer group were decreased (P＜0.05), while miR-146a levels were increased (P＜0.05). Compared with the non-metastatic group, the levels of PI, AUC, and miR-146a in the lymph node metastasis group were increased (P＜0.05), while the levels of TTP, MTT, and miR-34a were decreased (P＜0.05). The AUC of quantitative parameters of contrast-enhanced ultrasound and PBMC miR-34a and miR-146a for the diagnosis of thyroid cancer and lymph node metastasis was higher than the individual detection values of various indicators (P＜0.05). ConclusionThe combination of quantitative parameters of contrast-enhanced ultrasound and detection of miR-34a and miR-146a indicators in PBMC can enhance the early diagnosis and evaluation of lymph node metastasis in PTC. |
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