| 佟心,王伟,邸芳芳.脓毒症相关性脑病患者血清PCT、NSE、脑电双频指数变化及其临床意义.[J].中南医学科学杂志.,2024,(2):272-274. |
| 脓毒症相关性脑病患者血清PCT、NSE、脑电双频指数变化及其临床意义 |
| Change and clinical significance of serum PCT, NSE and bispectral index in patients with sepsis-related encephalopathy |
| 投稿时间：2023-05-18 修订日期：2023-01-25 |
| DOI：10.15972/j.cnki.43-1509/r.2024.02.029 |
| 中文关键词: 脓毒症相关性脑病 降钙素原 神经元特异性烯醇化酶 脑电双频指数 [ |
| 英文关键词:sepsis-related encephalopathy procalcitonin neuron specific enolase bispectral index |
| 基金项目:廊坊市科学技术项目(2019013025) |
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| 中文摘要: |
| 目的探究脓毒症相关性脑病(SAE)患者血清降钙素原(PCT)、神经元特异性烯醇化酶(NSE)、脑电双频指数(BIS)变化及其临床意义。 方法选择98例脓毒症患者,按ICU谵妄评估量表将其分为SAE组(n＝42)、非SAE组(n＝56)。比较两组患者血清PCT、NSE及BIS,分析PCT、NSE及BIS与格拉斯哥昏迷评分(Glasgow)的相关性,及其预测SAE的诊断效能,并进一步分析影响SAE发生的危险因素。 结果SAE组PCT、NSE水平高于非SAE组,BIS和Glasgow评分低于非SAE组(P＜0.05)。患者血清PCT、NSE水平与Glasgow评分呈负相关(P＜0.001),BIS与Glasgow评分呈正相关(P＜0.001)。血清PCT、NSE及BIS为SAE发生的独立危险因素,PCT、NSE及BIS对SAE具有良好的预测效能。 结论脓毒症患者血清CT、NSE及BIS是SAE发生的独立危险因素,在预测SAE发生中具有重要价值。 |
| 英文摘要: |
| AimTo explore the changes of serum procalcitonin (PCT), neuron-specific enolase (NSE), and bispectral index (BIS) in patients with sepsis-related encephalopathy (SAE) and its clinical significance. Methods98 patients with sepsis were selected and divided into SAE group (n＝42) and non-SAE group (n＝56) according to the ICU delirium assessment scale. The serum levels of PCT, NSE, and BIS between two groups of patients were compared, the correlation between PCT, NSE, and BIS with Glasgow coma score (Glasgow) was analyzed, and their diagnostic efficacy in predicting SAE was evaluated. Furthermore, the risk factors that affect the occurrence of SAE was analyzed. ResultsThe levels of PCT and NSE in the SAE group were higher than those in the non-SAE group, while the BIS and Glasgow score were lower than that in the non-SAE group (P＜0.05). The serum levels of PCT and NSE in patients were negatively correlated with Glasgow score (P＜0.001), while BIS was positively correlated with Glasgow score (P＜0.001). Serum PCT, NSE, and BIS are independent risk factors for the occurrence of SAE, and PCT, NSE, and BIS have good predictive power for SAE. ConclusionSerum CT, NSE, and BIS in sepsis patients are independent risk factors for the occurrence of SAE and have important value in predicting the occurrence of SAE. |
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