| 刘秋霞,龚志平,高艳飞,王媛媛.miR-506-3p、sST2和CEA在恶性胸腔积液患者中表达水平及诊断价值分析.[J].中南医学科学杂志.,2024,(2):232-235. |
| miR-506-3p、sST2和CEA在恶性胸腔积液患者中表达水平及诊断价值分析 |
| Analysis of the expression levels and diagnostic value of miR-506-3p, sST2, and CEA in patients with malignant pleural effusion |
| 投稿时间：2023-06-05 修订日期：2024-02-28 |
| DOI：10.15972/j.cnki.43-1509/r.2024.02.018 |
| 中文关键词: miR-506-3p 可溶性生长刺激表达基因2蛋白 癌胚抗原 恶性胸腔积液 诊断价值 [ |
| 英文关键词:miR-506-3p sST2 CEA malignant pleural effusion diagnostic value |
| 基金项目:河北省医学科学研究重点课题计划项目(20220415)；承德市科技计划项目(202002A081) |
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| 中文摘要: |
| 目的分析miR-506-3p、可溶性生长刺激表达基因2蛋白(sST2)和癌胚抗原(CEA)在恶性胸腔积液患者中表达水平及其诊断价值。 方法选取108例胸腔积液患者作为研究组,根据超声检查及病理检查结果,将32例结核性胸腔积液患者纳入结核性组,41例癌性胸腔积液患者和35例淋巴瘤性胸腔积液患者纳入恶性组。另随机抽取54例本院健康体检者纳入对照组。比较研究组患者及对照组健康体检者的血清sST2、CEA水平；比较恶性组与结核性组患者胸水miR-506-3p、sST2和CEA水平。采用ROC分析各指标对恶性胸腔积液的诊断价值。 结果血清sST2和CEA水平,恶性组＞结核性组＞对照组(P＜0.05)。与结核性组比较,恶性组胸水miR-506-3p水平降低(P＜0.05),而sST2和CEA水平升高(P＜0.05)。ROC结果显示,血清sST2、CEA及胸水miR-506-3p、sST2、CEA对恶性胸腔积液均具有诊断价值,且联合诊断的灵敏度最高。 结论在恶性胸腔积液患者中,胸水miR-506-3p低表达,而血清和胸水sST2、CEA高表达；对恶性胸腔积液具有一定诊断价值,且联合诊断的灵敏度最高。 |
| 英文摘要: |
| AimTo analyze the expression levels and diagnostic value of miR-506-3p, soluble growth stimulated expression gene 2 protein (sST2), and carcinoembryonic antigen (CEA) in patients with malignant pleural effusion. Methods108 patients with pleural effusion were selected as the study group. According to the results of ultrasound examination and pathological examination, 32 patients with tuberculosis pleural effusion were included in the tuberculosis group, and 41 patients with cancerous pleural effusion and 35 patients with lymphomatous pleural effusion were included in the malignant group. In addition, 54 cases of health examination patients in our hospital were randomly selected and included in the control group. The serum levels of sST2 and CEA between the patients in study group and the healthy individuals undergoing physical examinations in control group were compared. The levels of miR-506-3p, sST2, and CEA in pleural fluid of patients in the malignant group and the tuberculosis group were compared. The diagnostic value of various indicators for benign and malignant pleural effusion was analyzed by ROC. ResultsSerum sST2 and CEA levels, were in an order of malignant group＞tuberculosis group＞control group (P＜0.05). Compared with the tuberculosis group, miR-506-3p levels in pleural fluid of the malignant group was decreased (P＜0.05), while the levels of sST2 and CEA were increased (P＜0.05). The ROC results show that serum sST2, CEA, and miR-506-3p, sST2, CEA levels in pleural fluid have diagnostic value for malignant pleural effusion. Furthermore, the combined diagnosis had the highest sensitivity. ConclusionThe expression of miR-506-3p in pleural fluid is low, while the expression of sST2 and CEA in serum and pleural fluid is high in patients with malignant pleural effusion, which has certain diagnostic value for malignant pleural effusion. Furthermore, the combined diagnosis had the highest sensitivity. |
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