| 王宾红,蔡杰,张玥红.替勃龙治疗绝经后女性耳鸣的疗效及对其神经递质水平和睡眠质量的影响.[J].中南医学科学杂志.,2024,(2):228-231. |
| 替勃龙治疗绝经后女性耳鸣的疗效及对其神经递质水平和睡眠质量的影响 |
| Efficacy of tibolone on postmenopausal tinnitus women and its effect on neurotransmitter levels and sleep quality |
| 投稿时间：2023-05-17 修订日期：2023-09-10 |
| DOI：10.15972/j.cnki.43-1509/r.2024.02.017 |
| 中文关键词: 激素替代治疗 替勃龙 绝经后女性 耳鸣 神经递质 睡眠质量 [ |
| 英文关键词:hormone replacement therapy tibolone postmenopausal women tinnitus neurotransmitters sleep quality |
| 基金项目:北京市通州区科技计划项目(KJ2019CX011) |
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| 中文摘要: |
| 目的探讨替勃龙对绝经后女性耳鸣患者的疗效及对神经递质水平和睡眠质量的影响。 方法将106例收治的绝经后耳鸣患者随机分为对照组和观察组各53例。两组均接受围绝经期综合管理,对照组口服谷维素片,观察组口服替勃龙片+谷维素片。比较两组临床疗效及治疗前后改良Kupperman指数(KMI)、耳鸣障碍指标评估量表(THI)、匹兹堡睡眠质量指数(PSQI)评分,并对患者血清雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、5-羟色胺(5-HT)、去甲肾上腺素(NE)水平进行检测。结果观察组临床总有效率高于对照组(P＜0.05)。治疗后,两组KMI、THI及PSQI评分均降低,且观察低于对照组；两组血清E2水平及5-HT水平均升高,且观察组高于对照组,FSH水平、LH水平及NE水平均降低,且观察组低于对照组(P＜0.05)。 结论替勃龙可明显缓解绝经后女性耳鸣症状,改善其睡眠质量,对性激素和神经递质的调节可能是其作用机制。 |
| 英文摘要: |
| AimTo explore the efficacy of tibolone in postmenopausal women with tinnitus and its effect on neurotransmitter levels and sleep quality. Methods106 patients with postmenopausal tinnitus admitted were randomly divided into control group (n＝53) and observation group (n＝53). Both groups received comprehensive management of perimenopausal period. The control group took oryzanol tablets orally, and the observation group took tibolone tablets orally+oryzanol tablets orally. The clinical efficacy, Kupperman menopause index (KMI), Tinnitus handicap index (THI), Pittsburgh sleep quality index (PSQI) score and serum estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH),5-hydroxytryptamine (5-HT), norepinephrine (NE) levels before and after treatment were compared between the two groups. ResultsThe total clinical effective rate of the observation group was higher than that of the control group (P＜0.05). After treatment, the KMI, THI, and PSQI scores of both groups decreased, and the observation group was lower than the control group; The serum E2 and 5-HT levels in both groups increased, and the observation group was higher than the control group. The FSH, LH, and NE levels in both groups decreased, and the observation group was lower than the control group (P＜0.05). ConclusionTibolone can significantly improve tinnitus symptoms and sleep quality in postmenopausal women, and the regulation of sex hormones, neurotransmitter levels may be its mechanism of action. |
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