| 管龙,陈晨,沈蕾.MRI表观扩散系数在脑胶质瘤分级和IDH1基因分型中的临床意义.[J].中南医学科学杂志.,2024,(2):225-227. |
| MRI表观扩散系数在脑胶质瘤分级和IDH1基因分型中的临床意义 |
| The clinical significance of MRI apparent diffusion coefficient in brain glioma grading and IDH1 genotyping |
| 投稿时间：2023-06-30 修订日期：2024-01-11 |
| DOI：10.15972/j.cnki.43-1509/r.2024.02.016 |
| 中文关键词: MRI 脑胶质瘤 分级 IDH1基因 [ |
| 英文关键词:MRI brain glioma grading IDH1 gene |
| 基金项目:安徽省自然科学基金项目(2008086QC155) |
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| 中文摘要: |
| 目的探讨MRI表观扩散系数(ADC)在脑胶质瘤分级和异柠檬酸脱氢酶1(IDH1)基因分型中的临床意义。 方法回顾性收集脑胶质瘤患者60例,比较不同分级、不同IDH1基因型脑胶质瘤的ADC。ROC曲线分析ADC诊断不同分级脑胶质瘤的效能。 结果与低级别脑胶质瘤患者比较,高级别脑胶质瘤患者最小ADC、平均ADC、相对最小ADC、相对平均ADC显著降低(P＜0.05)；而不同IDH1基因型脑胶质瘤患者上述指标比较差异无显著性(P＞0.05)。ROC曲线分析结果显示,ADC对脑胶质瘤分级具有良好的诊断价值(P＜0.05)。 结论ADC对脑胶质瘤分级具有良好的诊断价值。 |
| 英文摘要: |
| AimTo investigate the clinical significance of MRI apparent diffusion coefficient (ADC) in glioma grading and isocitrate dehydrogenase 1 (IDH1) genotyping. MethodsA total of 60 patients with glioma were retrospectively collected, and the ADC values of glioma with different grades and different IDH1 genotypes were compared. ROC curve was used to analyze the efficacy of ADC in the diagnosis of different grades of glioma. ResultsCompared with patients with low-grade glioma, the minimum ADC, average ADC, relative minimum ADC and relative average ADC of patients with high-grade glioma were significantly lower (P＜0.05). ROC curve analysis showed that ADC had a good diagnostic value for glioma grading (P＜0.05). ConclusionADC has a good diagnostic value for glioma grading. |
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