| 文华,李迅,高鹏,胡新.SII联合CAR对小细胞肺癌预后的预测价值.[J].中南医学科学杂志.,2024,(2):217-220. |
| SII联合CAR对小细胞肺癌预后的预测价值 |
| Predictive value of SII combined with CAR in small cell lung cancer prognosis |
| 投稿时间：2022-10-30 修订日期：2023-11-22 |
| DOI：10.15972/j.cnki.43-1509/r.2024.02.014 |
| 中文关键词: 小细胞肺癌 全身免疫炎症指数 C反应蛋白/白蛋白比值 炎症 预后 [ |
| 英文关键词:SCLC SII CAR inflammation prognosis |
| 基金项目:安徽省科技公关计划项目(2020016) |
|
| 摘要点击次数: 40 |
| 全文下载次数: 29 |
| 中文摘要: |
| 目的分析全身免疫炎症指数(SII)联合C反应蛋白/白蛋白比值(CAR)对小细胞肺癌(SCLC)预后的预测价值。 方法回顾性选择本院256例SCLC患者,根据末次随访情况分为死亡组218例和存活组38例。收集两组患者入院时的临床资料,采用多因素Cox回归分析法分析SCLC患者全因死亡的独立危险因素,采用Kaplan-Meier法绘制生存曲线,采用ROC评估SII联合CAR预测SCLC死亡的临床效能。 结果存活组与死亡组红细胞分布宽度、中性粒细胞/淋巴细胞比值(NLR)、SII、CAR、D-二聚体、TNM分期比较,差异均有显著性(P＜0.05)。低SII组、低CAR组3年生存率分别高于高SII组、高CAR组(P＜0.05)。多因素Cox回归分析结果显示,NLR＞3.5、SII＞766×109个/L、CAR＞0.52、TNM Ⅳ期是SCLC患者全因死亡的独立危险因素。ROC分析显示,SII联合CAR预测SCLC患者全因死亡的AUC高于NLR联合CAR,预测性能最优。 结论SII联合CAR对SCLC患者预后具有较好的预测能力。 |
| 英文摘要: |
| AimTo analyze the prognostic value of systemic immune inflammation index (SII) combined with C-reactive protein/albumin ratio (CAR) in small cell lung cancer (SCLC). Methods256 patients with SCLC in our hospital were retrospectively analyzed. They were divided into 218 cases in the death group and 38 cases in the survival group according to the last follow-up. Clinical data of patients in both groups at the time of admission were collected, independent risk factors for all-cause mortality in SCLC patients were analyzed by multifactorial Cox regression analysis, survival curve was drawn by the Kaplan Meier method, and the clinical efficacy of SII combined with CAR for predicting SCLC mortality was assessed by ROC curve. ResultsThe differences in erythrocyte distribution width, neutrophil/lymphocyte ratio (NLR), SII, CAR, D-dimer, and TNM staging between the survival group and the death group were all significant (P＜0.05). The 3-year survival rates of the low SII group and low CAR group were higher than those of the high SII group and high CAR group, respectively (P＜0.05). The results of multifactorial Cox regression analysis showed that NLR＞3.5, SII＞766×109/L, CAR＞0.52, and TNM stage Ⅳ were the independent risk factors for all-cause mortality in SCLC patients. ROC curve showed that the AUC of SII combined with CAR to predict all-cause mortality in SCLC patients was higher than that of NLR combined with CAR, and therefore had the best predictive performance. ConclusionSII combination CAR has better predictive ability for prognosis in SCLC patients. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|