| 杨琪,李芳芳.外周血CD4＋CD25＋Treg细胞、TLR4、hCMV-IgM与动脉粥样硬化型急性脑梗死患者颈动脉粥样硬化的关系.[J].中南医学科学杂志.,2024,(1):123-127. |
| 外周血CD4＋CD25＋Treg细胞、TLR4、hCMV-IgM与动脉粥样硬化型急性脑梗死患者颈动脉粥样硬化的关系 |
| Relationship between peripheral blood CD4＋CD25＋Treg cells, TLR4, hCMV-IgM and carotid atherosclerosis in patients with atherosclerotic acute cerebral infarction |
| 投稿时间：2023-03-15 修订日期：2023-12-10 |
| DOI：10.15972/j.cnki.43-1509/r.2024.01.030 |
| 中文关键词: As-ACI 颈动脉粥样硬化 CD4＋CD25＋Treg细胞 TLR4 hCMV-IgM [ |
| 英文关键词:As-ACI carotid atherosclerosis CD4＋CD25＋Treg cell TLR4 hCMV-IgM |
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| 中文摘要: |
| 目的探讨外周血CD4＋CD25＋Treg细胞、TLR4、人巨细胞病毒(hCMV)-IgM与动脉粥样硬化型急性脑梗死(As-ACI)患者颈动脉粥样硬化的关系。 方法选取89例As-ACI患者(脑梗死组),另选取健康体检者43例(对照组)。根据颈内动脉超声结果将As-ACI患者分为内膜正常组、内膜增厚组、斑块组、狭窄组。比较各组外周血CD4＋CD25＋Treg细胞水平、单个核细胞TLR4表达水平、hCMV-IgM抗体阳性率和内膜中膜厚度(IMT)。分析As-ACI患者颈动脉狭窄的危险因素,分析CD4＋CD25＋Treg细胞、TLR4与IMT的相关性及其对颈动脉狭窄的预测价值。 结果脑梗死组CD4＋CD25＋Treg细胞、HDLC水平低于对照组,TLR4表达、hCMV-IgM抗体阳性率、TC、TG、LDLC、hs-CRP水平、IMT高于对照组(P＜0.05)。内膜正常组、内膜增厚组、斑块组、狭窄组CD4＋CD25＋Treg细胞水平依次降低,TLR4表达、hCMV-IgM抗体阳性率、IMT依次增高(P＜0.05)。CD4＋CD25＋Treg细胞水平与IMT呈负相关,TLR4表达与IMT呈正相关(P＜0.05)。高血压、CD4＋CD25＋Treg表达、TLR4表达、hCMV-IgM抗体阳性是As-ACI患者颈动脉狭窄的危险因素(P＜0.05)。CD4＋CD25＋Treg细胞、TLR4表达水平联合检测的预测价值高于单独检测(P＜0.05)。 结论外周血CD4＋CD25＋Treg细胞、TLR4、hCMV-IgM抗体阳性率与As-ACI患者颈动脉粥样硬化进展有关,外周血CD4＋CD25＋Treg细胞、TLR4联合可以较好预测病变过程。 |
| 英文摘要: |
| AimTo explore the relationship between peripheral blood CD4＋CD25＋Treg cells, TLR4, human cytomegalovirus (hCMV)-IgM and carotid atherosclerosis in patients with atherosclerotic acute cerebral infarction (As-ACI). MethodsSelect 89 As-ACI patients (cerebral infarction group) and 43 healthy individuals (control group) for physical examination.According to the ultrasound results of the internal carotid artery, As-ACI patients were divided into normal endometrial group, endometrial thickening group, plaque group, and stenosis group. Compare the levels of CD4＋CD25＋Treg cells in peripheral blood, TLR4 expression in mononuclear cells, hCMV-IgM antibody positivity rate, and intima-media thickness (IMT) among different groups.Analyze the risk factors for carotid artery stenosis in As-ACI patients, and examine the correlation between CD4＋CD25＋Treg cells, TLR4, and IMT, as well as their predictive value for carotid artery stenosis. ResultsThe levels of CD4＋CD25＋Treg cells and HDLC in the cerebral infarction group were lower than those in the control group, TLR4 expression, hCMV-IgM antibody positivity rate, TC, TG, LDLC, hs-CRP levels, IMT were higher in the cerebral infarction group than in the control group (P＜0.05). The levels of CD4＋CD25＋Treg cells in the normal endometrial group, endometrial thickening group, plaque group, and stenosis group decreased sequentially, while the expression of TLR4, the positivity rate of hCMV-IgM antibody and IMT increased sequentially (P＜0.05). The level of CD4＋CD25＋Treg cells is negatively correlated with IMT, while the expression of TLR4 is positively correlated with IMT (P＜0.05). Hypertension, CD4＋CD25＋Treg expression, TLR4 expression, and positive hCMV-IgM antibody are risk factors for carotid artery stenosis in As-ACI patients (P＜0.05). The predictive value of combined detection of CD4＋CD25＋Treg cells and TLR4 expression levels was higher than that of individual detection (P＜0.05). ConclusionThe levels of CD4＋CD25＋Treg cells, TLR4, and hCMV-IgM antibody positivity rate in peripheral blood are related to the progression of carotid atherosclerosis in As-ACI patients. The combination of CD4＋CD25＋Treg cells and TLR4 in peripheral blood can better predict the pathological process. |
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