| 陈佳美,季优苗.单核细胞/高密度脂蛋白胆固醇比值对急性脑桥梗死早期神经功能恶化的预测意义.[J].中南医学科学杂志.,2024,(1):102-105. |
| 单核细胞/高密度脂蛋白胆固醇比值对急性脑桥梗死早期神经功能恶化的预测意义 |
| Predictive significance of MHR for early neurological deterioration in acute pontine infarction |
| 投稿时间：2022-12-12 修订日期：2023-11-10 |
| DOI：10.15972/j.cnki.43-1509/r.2024.01.024 |
| 中文关键词: 急性脑桥梗死 早期神经功能恶化 单核细胞/高密度脂蛋白比值 [ |
| 英文关键词:acute pontine infarction early neurological deterioration MHR |
| 基金项目:江苏省卫生健康委医学科研立项项目(2021ZD0238) |
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| 中文摘要: |
| 目的探索单核细胞/高密度脂蛋白胆固醇比值(MHR)对急性脑桥梗死早期神经功能恶化(END)的预测意义。 方法回顾性选取803例急性脑桥梗死患者,按是否发生END分为END组及非END组。比较两组临床资料、MHR、梗死面积(IS)、梗死类型、入院NIHSS评分。分析MHR与IS、梗死类型的相关性。采用多因素Logistic分析急性脑桥梗死患者发生END的影响因素。采用ROC分析危险因素对发生END的预测价值。 结果两组患者年龄、发病至入院时间、住院时长、入院NIHSS评分及高血压比例比较差异有显著性(P＜0.05)。END组MHR、IS均高于非END组(P＜0.05),END组旁正中脑桥梗死(PPI)患者多于非END组(P＜0.05)。END组MHR与IS呈正相关(P＜0.001)。入院NIHSS评分、MHR、年龄、高血压、IS及PPI是影响脑桥梗死患者发生END的危险因素(P＜0.05)。MHR对脑桥梗死发生END有良好的预测价值。 结论MHR对急性脑桥梗死END有良好的预测价值,可为临床提供参考。 |
| 英文摘要: |
| AimTo explore the predictive significance of monocyte/high-density lipoprotein cholesterol ratio (MHR) for early neurological deterioration (END) in acute pontine infarction. Methods803 patients with acute pontine infarction were retrospectively selected and divided into END group and non-END group based on whether END occurred. Clinical data, MHR, infarct size (IS), infarct type, and admission NIHSS score were compared between two groups. The correlation between MHR and IS, as well as the type of infarction, were analyzed. Multivariate Logistic analysis was used to investigate the influencing factors of END in patients with acute pontine infarction. The predictive value of ROC on risk factors for the occurrence of END was also analyzed. ResultsAge, time from onset to admission, length of hospital stay, NIHSS score upon admission, and hypertension ratio in two groups of patients have significant difference (P＜0.05). The MHR and IS of the END group were higher than those of the non-END group (P＜0.05), and there were more paramedian pontine infarction (PPI) patients in the END group than in the non-END group (P＜0.05). The MHR in the END group was positively correlated with IS (P＜0.001). The admission NIHSS score, MHR, advanced age, hypertension, IS, and PPI are risk factors for the occurrence of END in patients with pontine infarction (P＜0.05). The combination of MHR and other indicators has good predictive value for the occurrence of END in pontine infarction. ConclusionMHR has good predictive value for acute pontine infarction (END), and can provide reference for clinical practice. |
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