| 丁永霞,金晶.孕早期血清FT3/FT4对妊娠合并甲状腺功能减退患者母婴结局的影响.[J].中南医学科学杂志.,2024,(1):87-90. |
| 孕早期血清FT3/FT4对妊娠合并甲状腺功能减退患者母婴结局的影响 |
| Effect of serum FT3/FT4 in early pregnancy on maternal and infant outcomes of pregnancy with hypothyroidism |
| 投稿时间：2023-06-19 修订日期：2023-12-10 |
| DOI：10.15972/j.cnki.43-1509/r.2024.01.020 |
| 中文关键词: 孕早期 FT3/FT4 甲状腺功能减退 母婴结局 [ |
| 英文关键词:first trimester FT3/FT4 hypothyroidism maternal and infant outcome |
| 基金项目:江苏省卫健委科研项目(K2019014) |
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| 中文摘要: |
| 目的探讨孕早期血清游离三碘甲状腺原氨酸(FT3)/FT4对妊娠合并甲状腺功能减退(甲减)患者母婴结局的影响。 方法选择122例妊娠合并甲减患者为甲减组,同期产检健康孕妇150例为健康组,甲减组根据母婴结局分为结局良好组和结局不良组,比较各组血清FT3、FT4、FT3/FT4。Logistic多因素回归分析母婴结局的影响因素；ROC评估FT3、FT4及FT3/FT4对母婴结局的预测价值。 结果血清FT3、FT4及FT3/FT4甲减组低于健康组,结局不良组低于结局良好组(P＜0.05)。体质指数、流产史、FT3、FT4、FT3/FT4是妊娠合并甲减患者母婴不良结局的危险因素(P＜0.05)。FT3/FT4预测妊娠合并甲减患者母婴结局的效能高于FT3、FT4(P＜0.05)。 结论FT3/FT4对妊娠合并甲减患者母婴结局有良好的预测价值,对临床诊疗具有指导作用。 |
| 英文摘要: |
| AimTo explore the effect of serum free triiodothyronine (FT3)/FT4 in early pregnancy on maternal and infant outcomes in patients with gestational hypothyroidism (hypothyroidism). Methods122 pregnant women with hypothyroidism were selected as the hypothyroidism group, and 150 healthy pregnant women who underwent prenatal examinations during the same period were selected as the healthy group. The hypothyroidism group was divided into a good outcome group and a poor outcome group based on maternal and infant outcomes. The serum FT3, FT4, and FT3/FT4 levels in each group were compared. Logistic multiple regression analysis was used to analyze the influencing factors on maternal and infant outcomes. ROC was used to evaluate the predictive value of FT3, FT4, and FT3/FT4 on maternal and infant outcomes. ResultsThe serum levels of FT3, FT4, and FT3/FT4 in the hypothyroidism group were lower than those in the healthy group, while those in the poor outcome group were lower than those in the good outcome group (P＜0.05). BMI, history of miscarriage, FT3, FT4, and FT3/FT4 are risk factors for adverse maternal and infant outcomes in pregnant women with hypothyroidism (P＜0.05). The efficacy of FT3/FT4 in predicting maternal and infant outcomes in pregnant women with hypothyroidism was higher than that of FT3 and FT4 (P＜0.05). ConclusionFT3/FT4 have good predictive value for maternal and infant outcomes in pregnant women with hypothyroidism, and have guiding significance for clinical diagnosis and treatment. |
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