| 王慧虹,张秀峰.HMGB1调控IL-17分泌与中性粒细胞性哮喘的研究进展.[J].中南医学科学杂志.,2023,(6):978-981. |
| HMGB1调控IL-17分泌与中性粒细胞性哮喘的研究进展 |
| Research progress of HMGB1 regulates IL-17 secretion in neutrophilic asthma |
| 投稿时间：2022-11-24 修订日期：2023-03-20 |
| DOI：10.15972/j.cnki.43-1509/r.2023.06.045 |
| 中文关键词: 非Th2型哮喘 Th2型哮喘 类固醇激素抵抗 中性粒细胞性哮喘 HMGB1 IL-17 [ |
| 英文关键词:non-Th2 asthma Th2 asthma steroid hormone resistance neutrophilic asthma HMGB1 IL-17 |
| 基金项目:国家自然科学基金项目(81960006) |
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| 中文摘要: |
| 哮喘是一种慢性炎症性疾病,根据不同炎症细胞类型分为Th2型和非Th2型。非Th2型哮喘的特征是类固醇激素抵抗,以中性粒细胞性哮喘为主。高迁移率族蛋白1(HMGB1)是一种属于警报素家族的染色质结合蛋白,作为促炎介质参与急性和慢性免疫疾病的发生发展,是非Th2型哮喘生物标志物。本文综述HMGB1调控IL-17分泌与中性粒细胞性哮喘的关系。 |
| 英文摘要: |
| Asthma is a chronic inflammatory disease, dividing into Th2 and non-Th2 types according to different inflammatory cell types. Non-Th2 asthma is characterized by steroid hormone resistance and dominated by neutrophilic asthma. High mobility group box 1 (HMGB1) is a chromatin binding protein belonging to the alertin family, which is involved in the occurrence and development of acute and chronic immune diseases as a pro-inflammatory mediator and a biomarker of non-Th2 asthma. This paper reviews the relationship between the regulation of IL-17 secretion by HMGB1 in neutrophilic asthma. |
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