| 潘贤明,邱斐斐,刘宁静.血清ALP、hs-CRP对冠心病PCI术后不良心血管事件的预测价值.[J].中南医学科学杂志.,2023,(5):752-755. |
| 血清ALP、hs-CRP对冠心病PCI术后不良心血管事件的预测价值 |
| Predictive value of serum ALP and hs-CRP on adverse cardiovascular events in coronary heart disease after PCI |
| 投稿时间：2022-10-11 修订日期：2023-08-29 |
| DOI：10.15972/j.cnki.43-1509/r.2023.05.033 |
| 中文关键词: 冠心病 经皮冠状动脉介入治疗 血清碱性磷酸酶 高敏C反应蛋白 不良心血管事件 [ |
| 英文关键词:coronary heart disease percutaneous coronary intervention alkaline phosphatase high-sensitivity C-reactive protein major adverse cardiovascular events |
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| 中文摘要: |
| 目的探讨血清碱性磷酸酶(ALP)、高敏C反应蛋白(hs-CRP)对冠心病(CHD)经皮冠状动脉介入治疗(PCI)术后不良心血管事件(MACE)发生的预测价值。 方法回顾性选取行PCI的CHD患者113例,依据是否发生MACE分为MACE组(n＝41)和非MACE组(n＝72)。比较两组临床资料和血清ALP、白蛋白(ALB)、hs-CRP水平。多因素Logistic回归分析CHD患者行PCI术后发生MACE的危险因素,ROC曲线分析ALP、hs-CRP对CHD患者行PCI后发生MACE的预测价值。 结果MACE组ALP和hs-CRP高于非MACE组,ALB低于非MACE组(P＜0.05)。MACE组年龄≥70岁、心肌梗死患者、BNP≥500 ng/L、左主干病变及支架数≥2个的占比均高于非MACE组(P＜0.05)；其他指标两组间比较差异无显著性(P＞0.05)。多因素Logistic回归分析显示,年龄、BNP、ALP、hs-CRP、冠心病类型、左主干病变及支架数≥2个均为CHD患者PCI术后发生MACE的危险因素(P＜0.05)。ROC曲线分析发现,血清ALP、hs-CRP联合检测对冠心病患者PCI术后MACE发生的预测价值最高(P＜0.05)。 结论血清ALP及hs-CRP联合检测可作为CHD患者PCI术后是否发生MACE的预测指标。 |
| 英文摘要: |
| AimTo explore the predictive value of serum alkaline phosphatase (ALP) and high-sensitivity C-reactive protein (hs-CRP) on occurrence of major adverse cardiovascular events (MACE) in coronary heart disease (CHD) after percutaneous coronary intervention (PCI). Methods113 patients with CHD undergoing PCI were retrospectively selected. According to whether or not MACE occurred, the patients were classified into MACE group (n＝41) and non-MACE group (n＝72). Clinical data and levels of serum ALP, albumin (ALB) and hs-CRP were compared between both groups. Multivariate Logistic regression analysis was used to analyze the risk factors for MACE occurrence in patients with CHD after PCI. ROC curve was applied to analyze the predictive value of ALP, ALB and hs-CRP on the occurrence of MACE in patients with CHD after PCI. ResultsThe ALP and hs CRP levels in the MACE group were higher than those in the non-MACE group, while the ALB levels were lower than those in the non-MACE group (P＜0.05). The proportion of patients with age ≥70 years old, myocardial infarction, BNP ≥500 ng/L, left main artery disease, and stents ≥2 in the MACE group was higher than that in the non-MACE group (P＜0.05); There was no significant difference in other indicators between the two groups (P＞0.05). Multivariate Logistic regression analysis showed that age, BNP, ALP, hs CRP, type of coronary heart disease, left main artery disease, and stents ≥2 were all risk factors for MACE in CHD patients after PCI (P＜0.05). ROC curve analysis showed that the combined detection of serum ALP and hs CRP had the highest predictive value for MACE occurrence in patients with coronary heart disease after PCI (P＜0.05). ConclusionThe combined detection of serum ALP and hs-CRP can be used as a predictor for postoperative MACE in patients with CHD after PCI. |
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