| 呼改琴,黄绡珕.早发型重度子痫前期患者血清sFlt1、NO、PLGF对胎儿生长受限的预测价值.[J].中南医学科学杂志.,2023,(5):749-751. |
| 早发型重度子痫前期患者血清sFlt1、NO、PLGF对胎儿生长受限的预测价值 |
| Predictive value of serum sFlt1, NO and PLGF for fetal growth restriction in patients with early-onset severe pre-eclampsia |
| 投稿时间：2022-05-26 修订日期：2023-08-15 |
| DOI：10.15972/j.cnki.43-1509/r.2023.05.032 |
| 中文关键词: 早发型重度子痫前期 胎儿生长受限 sFlt1 一氧化氮 胎盘生长因子 [ |
| 英文关键词:EOSP FGR sFlt1 nitric oxide placental growth factor |
| 基金项目: |
|
| 摘要点击次数: 329 |
| 全文下载次数: 236 |
| 中文摘要: |
| 目的探究早发型重度子痫前期(EOSP)患者血清可溶性血管内皮生长因子受体-1(sFlt1)、一氧化氮(NO)、胎盘生长因子(PLGF)水平对胎儿生长受限(FGR)的预测价值。 方法选择EOSP患者101例,根据是否发生FGR分为FGR组(n=53)及非FGR组(n=48)。比较两组血清sFlt1、NO、PLGF水平,并采用ROC曲线分析其对EOSP患者发生FGR的预测价值,比较两组分娩结局及新生儿结局。 结果FGR组发病时孕周及分娩时孕周均低于非FGR组(P＜0.05)；FGR组sFlt1水平高于非FGR组(P＜0.05),PLGF、NO水平低于非FGR组(P＜0.05)；sFlt1与PLGF、NO均呈负相关(P＜0.05)；采用ROC曲线分析可知,三项指标联合预测EOSP患者发生FGR的AUC高于单一指标的AUC,FGR组剖宫产发生率高于非FGR组(P＜0.05)；FGR组新生儿贫血、心脏发育不全、新生儿窒息、新生儿体质量偏低、入住NICU发生率均高于非FGR组(P＜0.05)。 结论血清sFlt1、NO、PLGF三项指标联合预测EOSP患者发生FGR的诊断价值较高。 |
| 英文摘要: |
| AimTo explore the predictive value of serum soluble fms-like tyrosine kinase-1 (sFlt1), nitric oxide (NO) and placental growth factor (PLGF) for fetal growth restriction (FGR) in patients with early-onset severe pre-eclampsia (EOSP). MethodsA total of 101 patients with EOSP were enrolled. According to presence or absence of FGR, they were divided into FGR group (n＝53) and non-FGR group (n＝48). The levels of serum sFlt1, NO and PLGF were compared between the two groups. The predictive value of the three indexes for FGR in EOSP patients was analyzed by ROC curves. The delivery outcomes and neonatal outcomes in the two groups were compared. ResultsThe gestational weeks of onset and delivery in FGR group were shorter compared with non-FGR group (P＜0.05). The level of sFlt1 in FGR group was higher than that in non-FGR group (P＜0.05), while levels of PLGF and NO were lower than those in non-FGR group (P＜0.05). The sFlt1 was negatively correlated with PLGF and NO (P＜0.05). ROC curves analysis showed that AUC of sFlt1 combined with PLGF and NO for predicting FGR was greater than that of single index. The incidence of cesarean section in FGR group was higher than that in non-FGR group (P＜0.05), and incidence of neonatal anemia, cardiac hypoplasia, neonatal asphyxia, low neonatal weight and stay in NICU was higher than that in non-FGR group (P＜0.05). ConclusionThe predictive value of serum sFlt1 combined with NO and PLGF is high for FGR in EOSP patients. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|