| 刘枫,张猛,孙卫和,沈建华,颜庆华,黄海源.标准大骨瓣减压术联合低温治疗对重型颅脑损伤患者预后的影响.[J].中南医学科学杂志.,2023,(5):745-748. |
| 标准大骨瓣减压术联合低温治疗对重型颅脑损伤患者预后的影响 |
| Effect of standard large trauma craniotomy combined with hypothermia on prognosis of patients with severe traumatic brain injury |
| 投稿时间：2022-09-22 修订日期：2023-08-25 |
| DOI：10.15972/j.cnki.43-1509/r.2023.05.031 |
| 中文关键词: 标准大骨瓣减压术 低温治疗 重型颅脑损伤 脑功能障碍 [ |
| 英文关键词:standard large bone flap decompression surgery low temperature treatment severe head injury brain dysfunction |
| 基金项目:盐城市医学科技发展计划项目(YK2021088) |
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| 中文摘要: |
| 目的探讨标准大骨瓣减压术(SLTC)联合低温治疗对重型颅脑损伤(STBI)患者预后的影响。 方法选取STBI患者90例,根据不同治疗方法分为低温组(SLTC+低温)和对照组(SLTC)。比较两组颅内压(ICP)、脑功能障碍评分(DRS)、血清角质纤维酸性蛋白(GFAP)、S-100β蛋白(S-100β)、髓鞘碱性蛋白(MBP)、神经元特异性烯醇化酶(NSE)、预后情况及并发症情况。 结果术后两组ICP、DRS评分、GFAP、S-100β、MBP、NSE水平均低于术前,且低温组低于同期对照组(P＜0.05)。术后3个月,低温组治疗总有效率高于对照组(P＜0.05)；低温组并发症发生率低于对照组(P＜0.05)。 结论SLTC联合低温治疗能够有效促进脑功能恢复,改善STBI患者预后,值得临床推广。 |
| 英文摘要: |
| AimTo investigate the impact of standard large bone flap decompression (SLTC) combined with hypothermia treatment on the prognosis of patients with severe traumatic brain injury (STBI). Methods90 STBI patients were selected and divided into a hypothermia group (SLTC+hypothermia) and a control group (SLTC) based on different treatment methods. Intracranial pressure (ICP), brain dysfunction score (DRS), serum keratinocyte fibrillary acidic protein (GFAP), S-100 β Protein (S-100 β), Myelin basic protein (MBP), neuron specific enolase (NSE), prognosis, and complications between the two groups were compared. ResultsICP, DRS scores, GFAP, S-100 β, the levels of MBP and NSE after operation were lower than those before surgery, and these indicators in hypothermia group was lower compared with the control group during the same period (P＜0.05). Three months after surgery, the total effective rate of the low-temperature group was higher than that of the control group (P＜0.05); The incidence of complications in the low-temperature group was lower than that in the control group (P＜0.05). ConclusionSLTC combined with hypothermia therapy can effectively promote brain function recovery and improve the prognosis of STBI patients, which is worthy of clinical promotion. |
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