| 李春序,侯可强,戚龙飞,房铭,王笑,尹艳萍,薛宁.二花地龙胶囊治疗气滞血瘀型腰椎间盘突出症患者疗效及对氧化应激指标、血清炎症因子的影响.[J].中南医学科学杂志.,2023,(5):733-736. |
| 二花地龙胶囊治疗气滞血瘀型腰椎间盘突出症患者疗效及对氧化应激指标、血清炎症因子的影响 |
| Efficacy of erhua dilong capsule in the treatment of lumbar disc herniation with qi stagnation and blood stasis type and its effect on oxidative stress and serum inflammatory factors |
| 投稿时间：2022-09-08 修订日期：2023-08-15 |
| DOI：10.15972/j.cnki.43-1509/r.2023.05.028 |
| 中文关键词: 二花地龙胶囊 腰椎间盘突出 氧化应激 炎症因子 [ |
| 英文关键词:erhua dilong capsules lumbar disc herniation oxidative stress inflammatory factors |
| 基金项目:青岛市中医药科研计划项目(2019-zyj009) |
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| 中文摘要: |
| 目的探讨二花地龙胶囊治疗气滞血瘀型腰椎间盘突出症患者(UDH)疗效及对氧化应激指标、血清炎症因子的影响。 方法选取150例气滞血瘀型UDH患者,随机均分为二花地龙组(二花地龙胶囊)、肠溶胶囊组(双氯芬酸钠双释放肠溶胶囊)、腰痛宁组(腰痛宁胶囊)。比较3组治疗疗效、不良反应发生率、氧化应激指标和血清炎症因子水平。 结果治疗后,二花地龙组总有效率高于肠溶胶囊组和腰痛宁组(P＜0.05)。各组治疗期间不良反应发生率比较,差异无统计学意义(P＞0.05)。与治疗前比较,治疗后3组日本骨科学会腰背痛评分、超氧化物歧化酶水平升高,Oswestry功能障碍指数、丙二醛、晚期蛋白氧化产物、白细胞介素-1β、白细胞介素-6、肿瘤坏死因子-α水平降低,二花地龙组较肠溶胶囊组和腰痛宁组更为显著(P＜0.05)。 结论二花地龙胶囊治疗气滞血瘀型UDH患者疗效显著,可有效提高抗氧化应激效果,降低炎症反应,值得临床推广。 |
| 英文摘要: |
| AimExplore the therapeutic effect of erhua dilong capsule on patients with lumbar disc herniation of qi stagnation and blood stasis type, as well as its impact on oxidative stress and serum inflammatory factors. Methods150 patients with qi stagnation and blood stasis type UDH were selected and randomly divided into erhua dilong group (erhua dilong capsule), enteric coated capsule group (diclofenac sodium dual release enteric coated capsule), and yaotongning group (yaotongning capsule). The treatment efficacy, incidence of adverse reactions, oxidative stress, and serum inflammatory factor levels among three groups were compared. ResultsAfter treatment, the total effective rate of the erhua dilong group was higher than that of the enteric coated capsule group and the yaotongning group (P＜0.05). There was no statistically significant difference in the incidence of adverse reactions during the treatment period among the groups (P＞0.05). After treatment, the JOA score and SOD levels in the three groups were increased, but ODI index, MDA, AOPP, and IL-1 β, IL-6, TNF-α level were significantly decreased in the erhua dilong group compared with the enteric coated capsule group and the yaotongning group (P＜0.05). ConclusionErhua dilong capsule has a significant therapeutic effect on patients with qi stagnation and blood stasis type UDH, which can effectively improve the antioxidant capacity and reduce inflammatory reactions. Therefore, it is worthy of clinical promotion. |
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