| 熊小奇,韦伟,康依,梁旭东,张林潮,张敬,罗长军,李君.尿白蛋白对非瓣膜性心房颤动患者血栓栓塞事件的预测价值.[J].中南医学科学杂志.,2023,(5):689-692. |
| 尿白蛋白对非瓣膜性心房颤动患者血栓栓塞事件的预测价值 |
| Predictive value of urinary albumin for thromboembolic events in patients with nonvalvular atrial fibrillation |
| 投稿时间：2023-04-26 修订日期：2023-06-28 |
| DOI：10.15972/j.cnki.43-1509/r.2023.05.015 |
| 中文关键词: 非瓣膜性心房颤动 血栓栓塞事件 尿白蛋白 预测价值 [ |
| 英文关键词:nonvalvular atrial fibrillation thromboembolic events urinary albumin predictive value |
| 基金项目:广西壮族自治区卫生健康委员会课题(Z20210670) |
| 作者 | 单位 | E-mail | | 熊小奇 | 柳州市柳铁中心医院,广西柳州 545007 | e-mail为xjnk69@163.com,e-mail为38740773@qq.com | | 韦伟 | 柳州市柳铁中心医院,广西柳州 545007 | | | 康依 | 柳州市柳铁中心医院,广西柳州 545007 | | | 梁旭东 | 柳州市柳铁中心医院,广西柳州 545007 | | | 张林潮 | 柳州市柳铁中心医院,广西柳州 545007 | | | 张敬 | 柳州市柳铁中心医院,广西柳州 545007 | | | 罗长军 | 柳州市柳铁中心医院,广西柳州 545007 | | | 李君 | 柳州市柳铁中心医院,广西柳州 545007 | e-mail为xjnk69@163.com,e-mail为38740773@qq.com |
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| 中文摘要: |
| 目的探究尿白蛋白对非瓣膜性心房颤动(NVAF)患者血栓栓塞事件的预测价值。 方法回顾性选取283例NVAF患者,根据出院后随访期间有无发生血栓栓塞事件分为事件组和无事件组,分析尿白蛋白对血栓栓塞事件的预测价值。 结果血栓栓塞事件发生率为12.72%。事件组高血压、CHA2DS2-VASc风险评分、左室射血分数、肺动脉收缩压、低密度脂蛋白胆固醇、尿酸、血清肌酐、尿白蛋白与无事件组比较,差异有统计学意义(P＜0.05)。ROC曲线分析显示,尿白蛋白预测NVAF患者发生血栓栓塞事件的AUC为0.846。高尿白蛋白组(＞68.6 mg/L)高血压、CHASDS2-VASc风险评分高危、肺动脉收缩压≥30 mmHg、血栓栓塞事件发生率及尿酸与血清肌酐水平高于低尿白蛋白组(≤68.6 mg/L)(P＜0.05)。高血压、肺动脉收缩压≥30 mmHg、CHA2DS2-VASc风险评分高危、尿白蛋白＞68.6 mg/L是NVAF患者发生血栓栓塞事件的危险因素(P＜0.05)。 结论尿白蛋白对NVAF患者发生血栓栓塞事件具有预测价值。 |
| 英文摘要: |
| AimTo investigated the predictive value of urinary albumin for thromboembolic events in patients with NVAF. Methods283 patients with NVAF were retrospectively selected and grouped according to whether thromboembolic events occurred during follow-up after discharge. The predictive value of urinary protein for thromboembolic events was analyzed. ResultsThe incidence of thromboembolic events was 12.72%. There were significant differences in hypertension, CHA2DS2-VASc risk score, left ventricular ejection fraction, pulmonary artery systolic blood pressure, low density lipoprotein cholesterol, uric acid, serum creatinine and urinary albumin level between the event group and the non-event group (P＜0.05), and the urinary albumin level was higher than that of the non-event group (P＜0.05).ROC results showed that AUC value as 0.846 could be used as the critical value to predict the thromboembolic events in NVAF patients. Hypertension, high CHASDS2-VASc risk score, pulmonary artery systolic blood pressure ≥30 mmHg, thromboembolic event incidence, uric acid and serum creatinine levels in patients with urine albumin＞68.6 mg/L were higher than those with urine albumin≤68.6 mg/L (P＜0.05). Hypertension, pulmonary artery systolic pressure≥30 mmHg, CHA2DS2-VASc risk score, urinary albumin ＞68.6 mg/L were risk factors for thromboembolic events in patients with NVAF (P＜0.05). ConclusionUrinary albumin has predictive value for thromboembolic events in NVAF patients. |
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